Nanoparticle drug delivery systems and their applications as targeted therapies for triple negative breast cancer
The therapeutic effect of highly malignant triple negative breast cancer (TNBC) is negatively
affected by the formation of tumor cell resistant clone and the severe toxicity of …
affected by the formation of tumor cell resistant clone and the severe toxicity of …
[HTML][HTML] Recent advances in drug delivery systems for targeting cancer stem cells
H Duan, Y Liu, Z Gao, W Huang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Cancer stem cells (CSCs) are a subpopulation of cancer cells with functions similar to those
of normal stem cells. Although few in number, they are capable of self-renewal, unlimited …
of normal stem cells. Although few in number, they are capable of self-renewal, unlimited …
Nanoparticles-based drug delivery and gene therapy for breast cancer: Recent advancements and future challenges
Breast cancer (BC) is amongst the most lethal cancer among females and conventional
treatment methods like surgery, radiotherapy and chemotherapy are not effective enough as …
treatment methods like surgery, radiotherapy and chemotherapy are not effective enough as …
Drug release and kinetic models of anticancer drug (BTZ) from a pH-responsive alginate polydopamine hydrogel: Towards cancer chemotherapy
A pH-sensitive polymeric carrier was developed in this study for local delivery of anticancer
drug bortezomib (BTZ) to cancer cells. Our strategy is based on the conjugation of BTZ to …
drug bortezomib (BTZ) to cancer cells. Our strategy is based on the conjugation of BTZ to …
Smart pH-responsive polyhydralazine/bortezomib nanoparticles for remodeling tumor microenvironment and enhancing chemotherapy
The clinical translation of nanomedicines has been impeded by the unfavorable tumor
microenvironment (TME), particularly the tortuous vasculature networks, which significantly …
microenvironment (TME), particularly the tortuous vasculature networks, which significantly …
Fungal proteases as emerging biocatalysts to meet the current challenges and recent developments in biomedical therapies: an updated review
With the increasing world population, demand for industrialization has also increased to
fulfill humans' living standards. Fungi are considered a source of essential constituents to …
fulfill humans' living standards. Fungi are considered a source of essential constituents to …
Potential and applications of nanocarriers for efficient delivery of biopharmaceuticals
During the past two decades, the clinical use of biopharmaceutical products has markedly
increased because of their obvious advantages over conventional small-molecule drug …
increased because of their obvious advantages over conventional small-molecule drug …
Polymeric nanoparticles—Tools in a drug delivery system in selected cancer therapies
M Madej, N Kurowska, B Strzalka-Mrozik - Applied Sciences, 2022 - mdpi.com
The increase in cancer cases is undoubtedly affecting the development of new therapeutic
approaches. Polymeric nanoparticles are of great interest. Due to their relatively small size …
approaches. Polymeric nanoparticles are of great interest. Due to their relatively small size …
The ubiquitin–proteasome system in breast cancer
D Han, L Wang, S Jiang, Q Yang - Trends in molecular medicine, 2023 - cell.com
Ubiquitin–proteasome system (UPS) is a selective proteolytic system that is associated with
the expression or function of target proteins and participates in various physiological and …
the expression or function of target proteins and participates in various physiological and …
Next-generation proteasome inhibitors for cancer therapy
Over 2 decades ago, the proteasome was considered a risky or even untenable therapeutic
target. Today, proteasome inhibitors are a mainstay in the treatment of multiple myeloma …
target. Today, proteasome inhibitors are a mainstay in the treatment of multiple myeloma …