WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

Since human embryonic stem cells were first differentiated to beating cardiomyocytes a
decade ago, interest in their potential applications has increased exponentially. This has …

Human pluripotent stem cells (hPSCs) offer the potential to generate large numbers of
functional cardiomyocytes from clonal and patient-specific cell sources. Here we show that …

Cardiovascular disease is a leading cause of death worldwide. The limited capability of
heart tissue to regenerate has prompted methodological developments for creating de novo …

The methods for the culture and cardiomyocyte differentiation of human embryonic stem
cells, and later human induced pluripotent stem cells (hiPSC), have moved from a complex …

Wnt proteins comprise a large family of highly conserved glycoproteins known for their role
in development, cell fate specification, tissue regeneration, and tissue homeostasis …

Human pluripotent stem cells (hPSCs) provide a valuable model for the study of human
development and a means to generate a scalable source of cells for therapeutic …

Human pluripotent stem cells (hPSCs), including embryonic stem cells and induced
pluripotent stem cells, are potentially useful in regenerative therapies for heart disease. For …

To harness the potential of human pluripotent stem cells (hPSCs), an abundant supply of
their progenies is required. Here, hPSC expansion as matrix-independent aggregates in …

Advances in our understanding of cardiovascular development have provided a roadmap for
the directed differentiation of human pluripotent stem cells (hPSCs) to the major cell types …