Molecular signaling mechanisms behind polyphenol-induced bone anabolism

E Torre - Phytochemistry Reviews, 2017 - Springer
For millennia, in the different cultures all over the world, plants have been extensively used
as a source of therapeutic agents with wide-ranging medicinal applications, thus becoming …

Rheumatoid arthritis molecular targets and their importance to flavonoid‐based therapy

AT Rufino, M Freitas, C Proença… - Medicinal Research …, 2024 - Wiley Online Library
Rheumatoid arthritis (RA) is a progressive, chronic, autoimmune, inflammatory, and systemic
condition that primarily affects the synovial joints and adjacent tissues, including bone …

[HTML][HTML] Eriodictyol inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes

Y Wang, Y Chen, Y Chen, B Zhou, X Shan… - Biomedicine & …, 2018 - Elsevier
Osteoarthritis (OA) is a degenerative disease of joints, which is closely associated with
cartilage degradation. Eriodictyol, a natural flavonoid compound, has been reported to have …

A mechanistic review of chinese medicine polyphenols on bone formation and resorption

Y Li, L Li, X Li, B Luo, Q Ye, H Wang, L Yang… - Frontiers in …, 2022 - frontiersin.org
Bone reconstruction includes a steady state system of bone formation and bone absorption.
This tight coupling requires subtle coordination between osteoblasts and osteoclasts. If this …

Bioactivity, Molecular Mechanism, and Targeted Delivery of Flavonoids for Bone Loss

AR Sharma, YH Lee, A Bat-Ulzii, S Chatterjee… - Nutrients, 2023 - mdpi.com
Skeletal disabilities are a prominent burden on the present population with an increasing life
span. Advances in osteopathy have provided various medical support for bone-related …

Eriodictyol inhibits survival and inflammatory responses and promotes apoptosis in rheumatoid arthritis fibroblast‐like synoviocytes through AKT/FOXO1 signaling

YC Liu, XN Yan - Journal of Cellular Biochemistry, 2019 - Wiley Online Library
Abstract 2‐(3, 4‐Dihydroxyphenyl)‐5, 7‐dihydroxy‐2, 3‐dihydrochromen‐4‐one
(eriodictyol), a flavonoid compound, was proved to possess anti‐inflammatory, antioxidative …

Piceatannol attenuates RANKL-induced osteoclast differentiation and bone resorption by suppressing MAPK, NF-κB and AKT signalling pathways and promotes …

L Yan, L Lu, F Hu, D Shetti… - Royal Society Open …, 2019 - royalsocietypublishing.org
Osteoclasts are multinuclear giant cells that have unique ability to degrade bone. The
search for new medicines that modulate the formation and function of osteoclasts is a …

[HTML][HTML] Eriodictyol protects skin cells from UVA irradiation-induced photodamage by inhibition of the MAPK signaling pathway

MF Nisar, T Liu, M Wang, S Chen, L Chang… - … of Photochemistry and …, 2022 - Elsevier
Solar UVA irradiation-generated reactive oxygen species (ROS) induces the expression of
matrix metalloproteinase 1 (MMP-1), leading to photoaging, however the molecular …

Pharmacokinetics and biodistribution of eriocitrin in rats

PS Ferreira, JA Manthey, MS Nery… - Journal of Agricultural …, 2021 - ACS Publications
Eriocitrin plays a role in the reduction of oxidative stress and inflammation linked to the
development of diabetes mellitus and atherosclerosis. We investigated the …

Anti-Osteoporotic and Anti-Adipogenic Effects of the Water Extract of Drynaria roosii Nakaike in Ovariectomized Mice Fed a High-Fat Diet

SA Jang, YH Hwang, T Kim, A Lee, H Ha - Molecules, 2019 - mdpi.com
In traditional oriental medicine, Drynaria roosii Nakaike is widely used in treating bone
diseases. Postmenopausal women are strongly associated with osteoporosis and obesity …