Although cardiac action potential (AP) generation and propagation have traditionally been
attributed exclusively to cardiomyocytes (CM), other cell types in the heart are also capable …

Anoctamin-1 (ANO1), also known as TMEM16A, is the most studied member of anoctamin
family of calcium-activated chloride channels with diverse cellular functions. ANO1 controls …

Calcium-activated chloride channels (CaCCs) have been implicated in hypertension;
however, the mechanism underlying their involvement is unknown. The aim of this study was …

The contribution of human atrial fibroblasts to cardiac physiology and pathophysiology is
poorly understood. Fibroblasts may contribute to arrhythmogenesis through fibrosis, or by …

Cardiac fibrosis is a key pathophysiological process that contributes to heart failure. Cardiac
resident fibroblasts, exposed to various stimuli, are able to trans-differentiate into …

Fluid and electrolyte releasing from secretory epithelia are elaborately regulated by
orchestrated activity of ion channels. The activity of chloride channel at the apical membrane …

Cardiac fibrosis is associated with most of heart diseases, but its molecular mechanism
remains unclear. Anoctamin-1 (ANO1), a calcium-activated chloride channels (CaCCs) …

Cardiac fibroblasts play an important role in cardiac matrix turnover and are involved in
cardiac fibrosis development. Ca 2+ is a driving belt in this phenomenon. This study …

Cerebrovascular remodeling is the leading factor for stroke and characterized by increased
extracellular matrix deposition, migration and proliferation of vascular smooth muscle cells …

Background/Aims: Calcium-activated chloride channels (CaCCs) regulate numerous
physiological processes including cell proliferation, migration, and extracellular matrix …