Early-onset neonatal sepsis in low-and middle-income countries: current challenges and future opportunities

K Sands, OB Spiller, K Thomson… - Infection and drug …, 2022 - Taylor & Francis
Neonatal sepsis is defined as a systemic infection within the first 28 days of life, with early-
onset sepsis (EOS) occurring within the first 72h, although the definition of EOS varies in …

Prevalence and clonal diversity of carbapenem-resistant Klebsiella pneumoniae causing neonatal infections: A systematic review of 128 articles across 30 countries

Y Hu, Y Yang, Y Feng, Q Fang, C Wang, F Zhao… - PLoS …, 2023 - journals.plos.org
Background Klebsiella pneumoniae is the most common pathogen causing neonatal
infections, leading to high mortality worldwide. Along with increasing antimicrobial use in …

Prevalence and risk factors for antimicrobial resistance among newborns with gram-negative sepsis

S Solomon, O Akeju, OA Odumade, R Ambachew… - PLoS …, 2021 - journals.plos.org
Introduction Newborn sepsis accounts for more than a third of neonatal deaths globally and
one in five neonatal deaths in Ethiopia. The first-line treatment recommended by WHO is the …

Clonal background and routes of plasmid transmission underlie antimicrobial resistance features of bloodstream Klebsiella pneumoniae

OO Ikhimiukor, NI Zac Soligno, IJ Akintayo… - Nature …, 2024 - nature.com
Bloodstream infections caused by the opportunistic pathogen Klebsiella pneumoniae are
associated with adverse health complications and high mortality rates. Antimicrobial …

NGSocomial Infections: High-resolution views of hospital-acquired infections through genomic epidemiology

AL Greninger, DM Zerr - Journal of the Pediatric Infectious …, 2021 - academic.oup.com
Hospital outbreak investigations are high-stakes epidemiology. Contacts between staff and
patients are numerous; environmental and community exposures are plentiful; and patients …

[HTML][HTML] Genomic insights into blaNDM-carrying carbapenem-resistant Klebsiella pneumoniae clinical isolates from a university hospital in Thailand

A Chukamnerd, R Pomwised, K Jeenkeawpiam… - Microbiological …, 2022 - Elsevier
The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates is a
serious threat to global health. Here, we elucidate the genetic features of bla NDM-carrying …

Epidemiological Analysis of Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae Outbreak in a Neonatal Clinic in Poland

A Pruss, P Kwiatkowski, H Masiuk, I Bilska… - Antibiotics, 2022 - mdpi.com
Klebsiella pneumoniae is one of the most common etiological agents isolated from epidemic
outbreaks in neonatal wards. We describe how an extended-spectrum β-lactamase …

CTX-M-15 Positive Escherichia coli and Klebsiella pneumoniae Outbreak in the Neonatal Intensive Care Unit of a Maternity Hospital in Ha'il, Saudi Arabia

M Almogbel, A Altheban, M Alenezi… - Infection and Drug …, 2021 - Taylor & Francis
Objective The aim of this study was to retrospectively characterize E. coli and K.
pneumoniae isolates obtained from neonates during a suspected NICU outbreak of infection …

Therapeutic Options and Outcomes for the Treatment of Neonates and Preterms with Gram-Negative Multidrug-Resistant Bacteria: A Systematic Review

L Chiusaroli, C Liberati, M Caseti, L Rulli, E Barbieri… - Antibiotics, 2022 - mdpi.com
(1) Background: Infections caused by multidrug-resistant (MDR) or extensively drug-resistant
(XDR) bacteria represent a challenge in the neonatal population due to disease severity and …

Successful Control of an Outbreak by Phenotypically Identified Extended-Spectrum Beta-Lactamase–Producing Klebsiella pneumoniae in a Neonatal Intensive Care …

E Priante, C Minotti, C Contessa, M Boschetto, P Stano… - Antibiotics, 2022 - mdpi.com
Background: Premature newborns represent a vulnerable population, at high risk of
acquiring nosocomial infections during neonatal intensive care unit (NICU) admission …