Insights into the molecular targets and emerging pharmacotherapeutic interventions for nonalcoholic fatty liver disease

CK Negi, P Babica, L Bajard, J Bienertova-Vasku… - Metabolism, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease
worldwide. With no Food and Drug Administration approved drugs, current treatment options …

Past, present and future perspectives in nonalcoholic fatty liver disease

AJ Sanyal - Nature reviews Gastroenterology & hepatology, 2019 - nature.com
Nonalcoholic fatty liver disease (NAFLD) was first described as a distinct clinical entity four
decades ago. However, the condition has become the centre of attention within hepatology …

Association of inflammatory cytokines with non-alcoholic fatty liver disease

Y Duan, X Pan, J Luo, X Xiao, J Li… - Frontiers in …, 2022 - frontiersin.org
Background Inflammatory cytokines have been considered to be significant factors
contributing to the development and progression of non-alcoholic fatty liver disease …

Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease

GI Smith, M Shankaran, M Yoshino… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND An increase in intrahepatic triglyceride (IHTG) is the hallmark feature of
nonalcoholic fatty liver disease (NAFLD) and is decreased by weight loss. Hepatic de novo …

GLP-1 receptor agonists in non-alcoholic fatty liver disease: current evidence and future perspectives

R Nevola, R Epifani, S Imbriani, G Tortorella… - International Journal of …, 2023 - mdpi.com
To date, non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease,
affecting up to 70% of patients with diabetes. Currently, there are no specific drugs available …

Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related …

D Porras, E Nistal, S Martínez-Flórez… - Free Radical Biology …, 2017 - Elsevier
Gut microbiota is involved in obesity, metabolic syndrome and the progression of
nonalcoholic fatty liver disease (NAFLD). It has been recently suggested that the flavonoid …

Pu-erh tea ameliorates obesity and modulates gut microbiota in high fat diet fed mice

J Ye, Y Zhao, X Chen, H Zhou, Y Yang, X Zhang… - Food Research …, 2021 - Elsevier
Obesity is regarded to be associated with fat accumulation, chronic inflammation, and gut
microbiota dysbiosis. Raw and ripened pu-erh tea extract (PETe) have the effect of reducing …

The regulation of hepatic fatty acid synthesis and partitioning: the effect of nutritional state

L Hodson, PJ Gunn - Nature Reviews Endocrinology, 2019 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is an increasing global public health burden.
NAFLD is strongly associated with type 2 diabetes mellitus, obesity and cardiovascular …

Molecular pathways in non-alcoholic fatty liver disease

A Berlanga, E Guiu-Jurado, JA Porras… - Clinical and …, 2014 - Taylor & Francis
Non-alcoholic fatty liver disease (NAFLD) is a clinicopathological change characterized by
the accumulation of triglycerides in hepatocytes and has frequently been associated with …

PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

S Francque, A Verrijken, S Caron, J Prawitt… - Journal of …, 2015 - Elsevier
Background & Aims Peroxisome proliferator-activated receptors (PPARs) have been
implicated in non-alcoholic steatohepatitis (NASH) pathogenesis, mainly based on animal …