Collagen, an extracellular protein, covers the entire human body and has several important
biological functions in normal physiology. Recently, collagen from non-human sources has …

The ternary complex of integrin-linked kinase (ILK), PINCH and parvin functions as a
signalling platform for integrins by interfacing with the actin cytoskeleton and many diverse …

Osteoarthritis is characterized by a progressive degradation of articular cartilage leading to
loss of joint function. The molecular mechanisms regulating pathogenesis and progression …

The insulin-signaling pathway leading to the activation of Akt/protein kinase B has been well
characterized except for a single step, the phosphorylation of Akt at Ser-473. Double …

Kinases control virtually all aspects of biology. Forty-eight human proteins have a kinase-like
domain that lacks at least one of the conserved catalytic residues; these proteins are …

Cancer development requires the acquisition of several capabilities that include increased
replicative potential, anchorage and growth-factor independence, evasion of apoptosis …

Integrin receptors connect the extracellular matrix to the actin cytoskeleton. This interaction
can be viewed as a cyclical liaison, which develops again and again at new adhesion sites …

Full activation of protein kinase B (PKB)/Akt requires phosphorylation on Thr-308 and Ser-
473 by 3-phosphoinositide-dependent kinase-1 (PDK1) and Ser-473 kinase (S473K) …

Small pore sizes inherent to electrospun matrices can hinder efficient cellular ingrowth. To
facilitate infiltration while retaining its extracellular matrix-like character, electrospinning was …

The ultimate goal in the design of biomimetic materials for use in tissue engineering as
permanent or resorbable tissue implants is to generate biocompatible scaffolds with …