Emerging roles of tRNA-derived fragments in cancer

M Fu, J Gu, M Wang, J Zhang, Y Chen, P Jiang, T Zhu… - Molecular cancer, 2023 - Springer
Abstract tRNA-derived fragments (tRFs) are an emerging category of small non-coding
RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance …

Action mechanisms and research methods of tRNA-derived small RNAs

Y Xie, L Yao, X Yu, Y Ruan, Z Li, J Guo - Signal transduction and …, 2020 - nature.com
Abstract tRNA-derived small RNAs (tsRNAs), including tRNA-derived fragments (tRFs) and
tRNA halves (tiRNAs), are small regulatory RNAs processed from mature tRNAs or …

Noncanonical roles of tRNAs: tRNA fragments and beyond

Z Su, B Wilson, P Kumar, A Dutta - Annual review of genetics, 2020 - annualreviews.org
As one of the most abundant and conserved RNA species, transfer RNAs (tRNAs) are well
known for their role in reading the codons on messenger RNAs and translating them into …

On the expanding roles of tRNA fragments in modulating cell behavior

R Magee, I Rigoutsos - Nucleic acids research, 2020 - academic.oup.com
The fragments that derive from transfer RNAs (tRNAs) are an emerging category of
regulatory RNAs. Known as tRFs, these fragments were reported for the first time only a …

Nuclear-mitochondrial interactions

BR Walker, CT Moraes - Biomolecules, 2022 - mdpi.com
Mitochondria, the cell's major energy producers, also act as signaling hubs, interacting with
other organelles both directly and indirectly. Despite having its own circular genome, the …

Extracellular vesicles-associated tRNA-derived fragments (tRFs): biogenesis, biological functions, and their role as potential biomarkers in human diseases

Q Weng, Y Wang, Y Xie, X Yu, S Zhang, J Ge… - Journal of Molecular …, 2022 - Springer
Traditionally, transfer RNAs (tRNAs) specifically decoded messenger RNA (mRNA) and
participated in protein translation. tRNA-derived fragments (tRFs), also known as tRNA …

Roles of mitochondria in the hallmarks of metastasis

AD Scheid, TC Beadnell, DR Welch - British Journal of Cancer, 2021 - nature.com
Although mitochondrial contributions to cancer have been recognised for approximately a
century, given that mitochondrial DNA (mtDNA) is dwarfed by the size of the nuclear genome …

The tRNA-derived fragment 5026a inhibits the proliferation of gastric cancer cells by regulating the PTEN/PI3K/AKT signaling pathway

L Zhu, Z Li, X Yu, Y Ruan, Y Shen, Y Shao… - Stem Cell Research & …, 2021 - Springer
Background Recently, tRNA-derived fragments (tRFs) have been shown to serve important
biological functions. However, the role of tRFs in gastric cancer has not been fully …

tsRFun: a comprehensive platform for decoding human tsRNA expression, functions and prognostic value by high-throughput small RNA-Seq and CLIP-Seq data

JH Wang, WX Chen, SQ Mei, YD Yang… - Nucleic acids …, 2022 - academic.oup.com
Abstract tRNA-derived small RNA (tsRNA), a novel type of regulatory small noncoding RNA,
plays an important role in physiological and pathological processes. However, the …

tRNAGlyGCC-Derived Internal Fragment (i-tRF-GlyGCC) in Ovarian Cancer Treatment Outcome and Progression

K Panoutsopoulou, T Dreyer, J Dorn, E Obermayr… - Cancers, 2021 - mdpi.com
Simple Summary In the precision medicine era, epithelial ovarian cancer (EOC) is
characterized by a high death-to-incidence rate and poor 5-year survival. The identification …