Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system
indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of …

Regulatory T cells (Tregs) characterized by the expression of the master transcription factor
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …

The success of cancer immunotherapy relies on the knowledge of the tumor
microenvironment and the immune evasion mechanisms in which the tumor, stroma, and …

INTRODUCTION The thymus is the critical organ for T cell development and T cell receptor
(TCR) repertoire formation, which shapes the landscape of adaptive immunity. T cell …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

Humans and their microbiota have coevolved a mutually beneficial relationship in which the
human host provides a hospitable environment for the microorganisms and the microbiota …

Immunosuppressive regulatory T cells (Tregs) provide a main mechanism of tumor immune
evasion. Targeting Tregs, especially in the tumor microenvironment (TME), continues to be …

The common cytokine receptor γ chain, γ c, is a component of the receptors for interleukin-2
(IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γ c results in X-linked …

Foxp3-expressing CD4+ regulatory T (Treg) cells play key roles in the prevention of
autoimmunity and the maintenance of immune homeostasis and represent a major barrier to …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …