BRAF, a cytoplasmic serine–threonine protein kinase, plays a critical role in cell signaling as
an activator within the mitogen-activated protein kinase (MAPK) pathway. The most common …

Despite a decrease in incidence over past decades, gastric cancer remains a major global
health problem. In the more recent period, survival has shown only minor improvement …

Abstract Zeolitic imidazolate framework-67 (ZIF-67) has been decorated with natural
biomaterials and DNA to develop a promising strategy and suitable and safe co-delivery …

STAT3 has been strongly implicated in human malignancies, and constitutive activation of
STAT3 serves a crucial role in cell survival, angiogenesis, immune evasion, and …

The RAS/RAF/MEK/MAPK and the PTEN/PI3K/AKT/mTOR pathways are key regulators of
proliferation and survival in human cancer cells. Selective inhibitors of different transducer …

Despite significant improvements in systemic chemotherapy over the last two decades, the
prognosis of patients with advanced gastric and gastroesophageal junction …

Inflammation and microRNAs are involved in human skin cancer; however, their molecular
mechanisms remain unclear. Further, a concern in skin cancer research is the identification …

Gastric cancer represents one of the most common cancer worldwide. Unfortunately, the
majority of patients present in advanced stage and outcome still remains poor with high …

Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft-tissue sarcomas
that represent an important clinical challenge, particularly given their strong tendency to …

Background Unresectable gastric cancer is associated with poor outcomes, with few
treatment options available after failure of cytotoxic chemotherapy. Clinical trials of targeted …