BACKGROUND When human populations expanded across the globe, they adapted
genetically to local environments in response to novel selection pressures. Drivers of …

Recent developments in genetics and genomics are providing a detailed and systematic
characterization of the genetic underpinnings of common metabolic diseases and traits …

High-coverage whole-genome sequence studies have so far focused on a limited number of
geographically restricted populations,,,, or been targeted at specific diseases, such as …

INTRODUCTION The consensus view on the peopling of the Americas is that ancestors of
modern Native Americans entered the Americas from Siberia via the Bering Land Bridge …

We report a genome-wide association scan in> 6,000 Latin Americans for pigmentation of
skin and eyes. We found eighteen signals of association at twelve genomic regions. These …

Impaired insulin secretion is a hallmark in type 2 diabetes mellitus (T2DM). THADA has
been identified as a candidate gene for T2DM, but its role in glucose homeostasis remains …

Objectives Obesity has become a global health public problem. The study aims to examine
the latest prevalence of overweight and obesity in China. Methods Data came from the …

Yakutia, Sakha Republic, in the Siberian Far East, represents one of the coldest places on
Earth, with winter record temperatures dropping below− 70° C. Nevertheless, Yakutian …

Little is known regarding the first people to enter the Americas and their genetic legacy.
Genomic analysis of the oldest human remains from the Americas showed a direct …

Arctic populations live in an environment characterized by extreme cold and the absence of
plant foods for much of the year and are likely to have undergone genetic adaptations to …