Effect of physico-chemical properties of nanoparticles on their intracellular uptake

P Sabourian, G Yazdani, SS Ashraf, M Frounchi… - International Journal of …, 2020 - mdpi.com
Cellular internalization of inorganic, lipidic and polymeric nanoparticles is of great
significance in the quest to develop effective formulations for the treatment of high morbidity …

Emerging application of nanomedicine-based therapy in acute respiratory distress syndrome

Y Xu, L Lv, Q Wang, Q Yao, L Kou, H Zhang - Colloids and Surfaces B …, 2024 - Elsevier
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are serious lung
injuries caused by various factors, leading to increased permeability of the alveolar-capillary …

[HTML][HTML] Dexamethasone-loaded ROS-responsive poly (thioketal) nanoparticles suppress inflammation and oxidative stress of acute lung injury

Z Zhai, W Ouyang, Y Yao, Y Zhang, H Zhang, F Xu… - Bioactive Materials, 2022 - Elsevier
Acute lung injury (ALI) is associated with excessive inflammatory response, leading to acute
respiratory distress syndrome (ARDS) without timely treatment. A fewer effective drugs are …

Exploring the intrinsic micro−/nanoparticle size on their in vivo fate after lung delivery

Q Liu, X Zhang, J Xue, J Chai, L Qin, J Guan… - Journal of Controlled …, 2022 - Elsevier
Micro−/nanocarriers due to their significant advantages are widely investigated in pulmonary
drug delivery. However, different size carriers have varied drug release rate, concealing the …

Targeted delivery of celastrol to glomerular endothelium and podocytes for chronic kidney disease treatment

Q Wu, J Wang, Y Wang, L Xiang, Y Tan, J Feng… - Nano Research, 2022 - Springer
The etiology of chronic kidney disease (CKD) is complex and diverse, which could be briefly
categorized to glomerular-or tubular-originated. However, the final outcomes of CKD are …

Safety evaluation of nanotechnology products

AJ Domb, G Sharifzadeh, V Nahum, H Hosseinkhani - Pharmaceutics, 2021 - mdpi.com
Nanomaterials are now being used in a wide variety of biomedical applications. Medical and
health-related issues, however, have raised major concerns, in view of the potential risks of …

Tissue‐Targeted Drug Delivery Strategies to Promote Antigen‐Specific Immune Tolerance

Y Rui, HB Eppler, AA Yanes… - Advanced healthcare …, 2023 - Wiley Online Library
During autoimmunity or organ transplant rejection, the immune system attacks host or
transplanted tissue, causing debilitating inflammation for millions of patients. There is no …

Evaluating the effect of synthesis, isolation, and characterisation variables on reported particle size and dispersity of drug loaded PLGA nanoparticles

BC Garms, H Poli, D Baggley, FY Han… - Materials …, 2021 - pubs.rsc.org
Poly (lactic-co-glycolic acid)(PLGA) nanoparticles have been extensively studied as carriers
of a wide variety of drugs. However, the variability in protocols and reporting in nanoscience …

Lipidated brush-PEG polymers as low molecular weight pulmonary drug delivery platforms

LM Kaminskas, NJ Butcher, CN Subasic… - Expert Opinion on …, 2024 - Taylor & Francis
Objectives Nanomedicines are being actively developed as inhalable drug delivery systems.
However, there is a distinct utility in developing smaller polymeric systems that can bind …

Pulmonary safety profile of esc peptides and esc-peptide-loaded poly (lactide-co-glycolide) nanoparticles: A promising therapeutic approach for local treatment of lung …

F Cappiello, B Casciaro, MR Loffredo, E Puglisi, Q Lin… - Pharmaceutics, 2022 - mdpi.com
In recent years, we have discovered Esc (1-21) and its diastereomer (Esc peptides) as
valuable candidates for the treatment of Pseudomonas lung infection, especially in patients …