Abstract Interleukin-7 (IL-7) is produced by stromal cells in lymphoid tissues and is required
for the development of T cells and for their persistence in the periphery. Unlike many other …

A diverse and well-balanced repertoire of T cells is thought to be crucial for the efficacious
defence against infection with new or re-emerging pathogens throughout life. In the last third …

Lymphopenia is frequent in advanced cancers and predicts the toxicity of chemotherapy. Its
effect on relapse and survival is uncertain. Its prognostic value for survival was analyzed in …

Interleukin-7 (IL-7) is a homeostatic cytokine for resting T cells with increasing serum and
tissue levels during T cell depletion. In preclinical studies, IL-7 therapy exerts marked …

Aging is linked to deficiencies in immune responses and increased systemic inflammation.
To unravel the regulatory programs behind these changes, we applied systems immunology …

Objectives We hypothesized that immune response may contribute to progression of
coronavirus disease-19 (COVID-19) at the second week of illness. Therefore, we compared …

Background Understanding the memory T-cell response to severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is crucial for assessing the longevity of protective …

We lack a mechanistic understanding of aging-mediated changes in mitochondrial
bioenergetics and lipid metabolism that affect T cell function. The bioactive sphingolipid …

Effective T-cell therapy against cancer is dependent on the formation of long-lived, stem cell–
like T cells with the ability to self-renew and differentiate into potent effector cells. Here, we …

Aging-associated changes in the function of the immune system are referred to as senescent
immune remodeling (SIR). Here we review the current understanding on the cellular and …