Cellular membranes function as permeability barriers that separate cells from the external
environment or partition cells into distinct compartments. These membranes are lipid …

Genome editing is the modification of genomic DNA at a specific target site in a wide variety
of cell types and organisms, including insertion, deletion and replacement of DNA, resulting …

Endothelial cells (ECs) normally form an anticoagulant surface under physiological
conditions, but switch to support coagulation following pathogenic stimuli. This switch …

Limb-girdle muscular dystrophy type 2L (LGMD2L) is a myopathy arising from mutations in
ANO5; however, information about the contribution of ANO5 to muscle physiology is lacking …

For many years, scientists have aspired to edit any DNA segment of living organisms
precisely, and with the discovery of CRISPR/Cas9, they have moved closer to achieving …

The preimplantation development of mammals generally follows the same plan. It starts with
the formation of a totipotent zygote, and through consecutive cleavage divisions and …

ANO5 encodes transmembrane protein 16E (TMEM16E), an intracellular calcium-activated
chloride channel in the endoplasmic reticulum. Mutations in ANO5 are associated with …

Autosomal recessive mutations in Anoctamin 5 (ANO5/TMEM16E), a member of the
transmembrane 16 (TMEM16) family of Ca2+-activated ion channels and phospholipid …

Anoctaminopathy-5 refers to a group of hereditary skeletal muscle or bone disorders due to
mutations in the anoctamin 5 (ANO5)-encoding gene, ANO5. ANO5 is a 913-amino acid …

Rabbits are one of the most used experimental animals for investigating the mechanisms of
human cardiovascular disease and lipid metabolism because they are phylogenetically …