The extracellular matrix (ECM) is present in all tissues and crucial in maintaining normal
tissue homeostasis and function. Defects in ECM synthesis and remodeling can lead to …

Metabolic reprogramming contributes to the progression and prognosis of various kidney
diseases. Glutamine is the most abundant free amino acid in the body and participates in …

Nitropyrene (1-NP), a typical nitro-polycyclic aromatic hydrocarbon, is a developmental
toxicant. This study was to evaluate gestational 1-NP-induced anxiety-like behavior in male …

Fibrosis, or excessive scarring, is characterized by the emergence of alpha-smooth muscle
actin (αSMA)-expressing myofibroblasts and the excessive accumulation of fibrotic …

Background Idiopathic pulmonary fibrosis (IPF) is a progressive and debilitating respiratory
disease with a median survival of less than 5 years. In recent years, glutamine has been …

Metabolic reprogramming underlies the etiology and pathophysiology of respiratory
diseases such as asthma, idiopathic pulmonary fibrosis (IPF), and chronic obstructive …

Introduction Glutamine metabolic reprogramming, mediated by glutaminase (GLS), is an
important signal during pulmonary fibrosis (PF) progression. Tanshinone IIA (Tan IIA) is a …

Metabolomics significantly impacts drug discovery and precise disease management. This
study meticulously assesses the metabolite profiles of cells treated with Crocin …

Epigenetic modifications are involved in fibrotic diseases, such as idiopathic pulmonary
fibrosis (IPF), and contribute to the silencing of anti‐fibrotic genes. H3K27me3, a key …

Sepsis-induced myocardial dysfunction (SIMD) is the main cause of mortality in sepsis. In
this study, we identified Polo-like kinase 1 (Plk-1) is a promoter of SIMD. Plk-1 expression …