The success of immunotherapy in oncology underscores the vital role of the immune system
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …

Tumour necrosis factor-α (TNF) is a multifunctional cytokine. First recognized as an
endogenous soluble factor that induces necrosis of solid tumours, TNF became increasingly …

Cell function and activity are regulated through integration of signaling, epigenetic,
transcriptional, and metabolic pathways. Here, we introduce INs-seq, an integrated …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

Memory for antigen is a defining feature of adaptive immunity. Antigen-specific lymphocyte
populations show an increase in number and function after antigen encounter and more …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

Infiltration of memory CD4+ T cells in synovial joints of Rheumatoid Arthritis (RA) patients
has been reported since decades. Moreover, several genome wide association studies …

Obesity and its comorbidities are closely related to the inflammatory environment created by
expanded adipose tissue. Several mechanisms trigger inflammation in adipose tissue …

The combination of targeted therapy with immune checkpoint inhibition (ICI) is an area of
intense interest. We studied the interaction of fibroblast growth factor receptor (FGFR) …

The severe cases of Coronavirus Disease 2019 (COVID-19) frequently exhibit excessive
inflammatory responses, acute respiratory distress syndrome (ARDS), coagulopathy, and …