Background The liver is a key regulator of systemic energy homeostasis and can sense and
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …

This review summarizes the latest findings in the literature of Angiopoietin-2 (Ang-2),
Tyrosine-protein kinase receptor (Tie-2) complex, and faricimab along with their involvement …

Abstract In mammals, triglyceride (TG), the main form of lipids for storing and providing
energy, is stored in white adipose tissue (WAT) after food intake, while during fasting it is …

Objective Several members of the angiopoietin-like (ANGPTL) family of proteins, including
ANGPTL3 and ANGPTL8, regulate lipoprotein lipase (LPL) activity. Deficiency in either …

Exercise activates a plethora of metabolic and signalling pathways in skeletal muscle and
other organs causing numerous systemic beneficial metabolic effects. Thus, regular exercise …

The liver plays a key role in maintaining energy homeostasis by sensing and responding to
changes in nutrient status under various metabolic conditions. Recently highlighted as a …

Despite the best pharmacologic tools available, cardiovascular diseases (CVDs) remain a
major cause of morbidity and mortality in developed countries. After 2 decades of research …

BACKGROUND: ANGPTL3 (angiopoietin-like 3) is a therapeutic target for reducing plasma
levels of triglycerides and low-density lipoprotein cholesterol. A recent trial with vupanorsen …

Hypertriglyceridemia is a risk factor for a series of diseases, such as cardiovascular disease
(CVD), diabetes and nonalcoholic fatty liver disease (NAFLD). Angiopoietin-like proteins …

Background Hypertension is a risk factor for both cardiovascular diseases (CVDs) and type
2 diabetes (T2D). Angiopoietin-like proteins (ANGPTLs), mainly ANGPTL3, ANGPTL4 and …