Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis
The endoplasmic reticulum (ER) is a cellular organelle where secretory and membrane
proteins, as well as lipids, are synthesized and modified. When cells are subjected to ER …
proteins, as well as lipids, are synthesized and modified. When cells are subjected to ER …
Oxidative stress, unfolded protein response, and apoptosis in developmental toxicity
Physiological development requires precise spatiotemporal regulation of cellular and
molecular processes. Disruption of these key events can generate developmental toxicity in …
molecular processes. Disruption of these key events can generate developmental toxicity in …
Neural stem cells to cerebral cortex: emerging mechanisms regulating progenitor behavior and productivity
This review accompanies a 2016 SFN mini-symposium presenting examples of current
studies that address a central question: How do neural stem cells (NSCs) divide in different …
studies that address a central question: How do neural stem cells (NSCs) divide in different …
Endoplasmic reticulum protein quality control failure in myelin disorders
VG Volpi, T Touvier, M D'Antonio - Frontiers in molecular …, 2017 - frontiersin.org
Reaching the correct three-dimensional structure is crucial for the proper function of a
protein. The endoplasmic reticulum (ER) is the organelle where secreted and …
protein. The endoplasmic reticulum (ER) is the organelle where secreted and …
The unfolded protein response and cholesterol biosynthesis link Luman/CREB3 to regenerative axon growth in sensory neurons
We recently revealed that the axon endoplasmic reticulum resident transcription factor
Luman/CREB3 (herein called Luman) serves as a unique retrograde injury signal in …
Luman/CREB3 (herein called Luman) serves as a unique retrograde injury signal in …
Cerebral dopamine neurotrophic factor regulates multiple neuronal subtypes and behavior
YC Chen, D Baronio, S Semenova… - Journal of …, 2020 - Soc Neuroscience
Cerebral dopamine neurotrophic factor (CDNF) protects dopaminergic neurons against toxic
damage in the rodent brain and is in clinical trials to treat Parkinson's disease patients. Yet …
damage in the rodent brain and is in clinical trials to treat Parkinson's disease patients. Yet …
The vertebrate-specific Kinesin-6, Kif20b, is required for normal cytokinesis of polarized cortical stem cells and cerebral cortex size
KM Janisch, VM Vock, MS Fleming, A Shrestha… - …, 2013 - journals.biologists.com
Mammalian neuroepithelial stem cells divide using a polarized form of cytokinesis, which is
not well understood. The cytokinetic furrow cleaves the cell by ingressing from basal to …
not well understood. The cytokinetic furrow cleaves the cell by ingressing from basal to …
[HTML][HTML] Endoplasmic reticulum and Golgi stress in microcephaly
Microcephaly is a neurodevelopmental condition characterized by a small brain size
associated with intellectual deficiency in most cases and is one of the most frequent clinical …
associated with intellectual deficiency in most cases and is one of the most frequent clinical …
ALS‐associated endoplasmic reticulum proteins in denervated skeletal muscle: implications for motor neuron disease pathology
CM Jesse, E Bushuven, P Tripathi… - Brain …, 2017 - Wiley Online Library
Alpha‐motoneurons and muscle fibres are structurally and functionally interdependent. Both
cell types particularly rely on endoplasmic reticulum (ER/SR) functions. Mutations of the ER …
cell types particularly rely on endoplasmic reticulum (ER/SR) functions. Mutations of the ER …
Thalamic neuronal specification and early circuit formation
H Gezelius, G López‐Bendito - Developmental Neurobiology, 2017 - Wiley Online Library
The thalamus is a central structure of the brain, primarily recognized for the relay of incoming
sensory and motor information to the cerebral cortex but also key in high order intracortical …
sensory and motor information to the cerebral cortex but also key in high order intracortical …