Clustered miRNAs and their role in biological functions and diseases

SP Kabekkodu, V Shukla, VK Varghese… - Biological …, 2018 - Wiley Online Library
MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …

The role of microRNAs in the mammary gland development, health, and function of cattle, goats, and sheep

AP Dysin, OY Barkova, MV Pozovnikova - Non-coding RNA, 2021 - mdpi.com
Milk is an integral and therefore complex structural element of mammalian nutrition.
Therefore, it is simple to conclude that lactation, the process of producing milk, is as complex …

Predicting microRNA-disease associations based on improved microRNA and disease similarities

W Lan, J Wang, M Li, J Liu, FX Wu… - IEEE/ACM transactions …, 2016 - ieeexplore.ieee.org
MicroRNAs (miRNAs) are a type of non-coding RNAs with about~ 22nt nucleotides.
Increasing evidences have shown that miRNAs play critical roles in many human diseases …

The pause-initiation limit restricts transcription activation in human cells

S Gressel, B Schwalb, P Cramer - Nature communications, 2019 - nature.com
Eukaryotic gene transcription is often controlled at the level of RNA polymerase II (Pol II)
pausing in the promoter-proximal region. Pausing Pol II limits the frequency of transcription …

TGFβ receptor inhibitor galunisertib is linked to inflammation-and remodeling-related proteins in patients with pancreatic cancer

D Melisi, R Garcia-Carbonero, T Macarulla… - Cancer chemotherapy …, 2019 - Springer
Purpose Galunisertib, the first small molecule transforming growth factor beta (TGFβ)
receptor inhibitor, plus gemcitabine resulted in the improvement of survival in patients with …

Ly6G+ neutrophil-derived miR-223 inhibits the NLRP3 inflammasome in mitochondrial DAMP-induced acute lung injury

Z Feng, S Qi, Y Zhang, Z Qi, L Yan, J Zhou, F He… - Cell death & …, 2017 - nature.com
MicroRNA (miRNA) mediates RNA interference to regulate a variety of innate immune
processes, but how miRNAs coordinate the mechanisms underlying acute lung injury/acute …

miR-424 (322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy

R Rodriguez-Barrueco, EA Nekritz… - Genes & …, 2017 - genesdev.cshlp.org
The female mammary gland is a very dynamic organ that undergoes continuous tissue
remodeling during adulthood. Although it is well established that the number of menstrual …

miR‐424‐5p reduces ribosomal RNA and protein synthesis in muscle wasting

M Connolly, R Paul, R Farre‐Garros… - Journal of cachexia …, 2018 - Wiley Online Library
Background A loss of muscle mass occurs as a consequence of a range of chronic and
acute diseases as well as in older age. This wasting results from an imbalance of protein …

miR-322/-503 cluster is expressed in the earliest cardiac progenitor cells and drives cardiomyocyte specification

X Shen, B Soibam, A Benham, X Xu… - Proceedings of the …, 2016 - National Acad Sciences
Understanding the mechanisms of early cardiac fate determination may lead to better
approaches in promoting heart regeneration. We used a mesoderm posterior 1 (Mesp1) …

[HTML][HTML] MicroRNA-424 inhibits Akt3/E2F3 axis and tumor growth in hepatocellular carcinoma

H Yang, W Zheng, X Shuai, RM Chang, L Yu, F Fang… - Oncotarget, 2015 - ncbi.nlm.nih.gov
By comparing the expression profiles of miRNAs in different subtypes of HCC, we identified
miR-424 as a HCC related miRNA. We found that the expression of miR-424 was …