Thomsen-Friedenreich antigen: the “hidden” tumor antigen

S Goletz, Y Cao, A Danielczyk, P Ravn… - Glycobiology and …, 2003 - Springer
Carbohydrate tumor antigens on glycoproteins and glycolipids are targets for active and
passive cancer immunotherapy. These highly abundant antigens are de novo expressed or …

Expression of thomsen‐friedenreich‐related antigens in primary and metastatic colorectal carcinomas. A reevaluation

Y Cao, UR Karsten, W Liebrich, W Haensch… - Cancer, 1995 - Wiley Online Library
Background. Expression of the pancarcinoma Thomsen‐Friedenreich (TF) carbohydrate
antigen or, more correctly, hapten, in colorectal carcinomas is not generally agreed on …

Antigenic properties of human erythrocyte glycophorins

E Lisowska - The molecular immunology of complex carbohydrates, 1988 - Springer
The name of glycophorin was given by Marchesi et al.(1972) to the major sialoglycophorin of
human erythrocyte membranes, known earlier as the glycoprotein carrying blood group M …

Permanent exposure of mucin-secreting HT-29 cells to benzyl-N-acetyl-α-D-galactosaminide induces abnormal O-glycosylation of mucins and inhibits constitutive and …

S Hennebicq-Reig, T Lesuffleur, C Capon… - Biochemical …, 1998 - portlandpress.com
Previous work has shown that treatment of HT-29 methotrexate (MTX) cells with benzyl-N-
acetyl-α-d-galactosaminide results in profound changes in mucin oligosaccharide chains. To …

β-Elimination ofO-Glycans from Glycoproteins Transferred to Immobilon P Membranes: Method and Some Applications

M Duk, M Ugorski, E Lisowska - Analytical biochemistry, 1997 - Elsevier
Selective β-elimination ofO-glycans from glycoproteins transferred from electrophoretic gels
onto Immobilon P membranes is described. The experiments were performed with …

Benzyl-N-acetyl-α-d-galactosaminide inhibits the sialylation and the secretion of mucins by a mucin secreting HT-29 cell subpopulation

P Delannoy, I Kim, N Emery, C de Bolos, A Verbert… - Glycoconjugate …, 1996 - Springer
We have analysed the mucins synthesized by the HT-29 MTX cell subpopulation, derived
from the HT-29 human colon carcinoma cells through a selective pressure with methotrexate …

Use of O-glycosylation-defective human lymphoid cell lines and flow cytometry to delineate the specificity of Moluccella laevis lectin and monoclonal antibody 5F4 for …

M Thurnher, H Clausen, N Sharon, EG Berger - Immunology letters, 1993 - Elsevier
Abstract The Tn antigen (GalNAcα1-O-Ser/Thr) is a disease-related O-linked (mucin-type)
carbohydrate neoantigen which is expressed in idiopathic Tn syndrome, AIDS, T-cell …

Multivalent scFv display of phagemid repertoires for the selection of carbohydrate-specific antibodies and its application to the Thomsen–Friedenreich antigen

P Ravn, A Danielczyk, KB Jensen, P Kristensen… - Journal of molecular …, 2004 - Elsevier
The Thomsen–Friedenreich disaccharide (TF) is a promising target antigen for tumor
immunotherapy, since it is almost exclusively expressed in carcinoma tissues. The TF …

MUC1 in human and murine mammary carcinoma cells decreases the expression of core 2 β1,6-N-acetylglucosaminyltransferase and β-galactoside α2,3 …

A Solatycka, T Owczarek, F Piller, V Piller, B Pula… - …, 2012 - academic.oup.com
A good correlation between the expression of mucin1 (MUC1) and T antigen was found in
breast cancer tumors and breast cancer cell lines, especially after treatment with …

A New Monoclonal Antibody (A78-G/A7) to the Thomsen—Friedenreich Pan-Tumor Antigen

U Karsten, G BUTSCHAK, YI Cao, S GOLETZ… - Hybridoma, 1995 - liebertpub.com
A new monoclonal antibody to the Thomsen—Friedenreich (TF) antigen (or, more precisely,
epitope; Galβl-3GalNAc-) has been developed that is specific for both anomeric forms of this …