Researchers worldwide are taking advantage of novel, commercially available,
technologies, such as ion mobility mass spectrometry (IM‐MS), for metabolomics and …

Neutrophils are a critical element of host defense and are rapidly recruited to inflammatory
sites. Such sites are frequently limited in oxygen and/or nutrient availability, presenting a …

Lung emphysema and chronic bronchitis are the two most common causes of chronic
obstructive pulmonary disease. Excess macrophage elastase MMP-12, which is …

The cellular lipidome comprises thousands of unique lipid species. Here, using mass
spectrometry-based targeted lipidomics, we characterize the lipid landscape of human and …

The importance of fatty acid (FA) metabolism in cancer is well-established, yet the
mechanisms underlying metabolic reprogramming remain elusive. Here, we identify …

Abstract Background and Aim Acutely decompensated of cirrhosis is a heterogeneous
clinical entity associated with moderate mortality. In some patients, this condition develops …

Macrophages and lymphocytes demonstrate metabolic plasticity, which is dependent partly
on their state of activation and partly on the availability of various energy yielding and …

Inflammation is a life-saving immune reaction occurring in response to invading pathogens.
Nonetheless, inflammation can also occur in an uncontrolled, unrestricted manner, leading …

Background Asthma is a chronic respiratory disease with significant heterogeneity in its
clinical presentation and pathobiology. There is need for improved understanding of …

Regulatory T cells (Tregs) suppress pro-inflammatory conventional T cell (Tconv) responses.
As lipids impact cell signaling and function, we compare the lipid composition of CD4+ …