Fibrinolysis is regulated by specific molecular interactions between its main components.
Activation of plasminogen by tissue-type plasminogen activator (t-PA) is enhanced in the …

The plasmin–antiplasmin system plays a key role in blood coagulation and fibrinolysis.
Plasmin and α 2-antiplasmin are primarily responsible for a controlled and regulated …

In response to vessel injury (or other pathological conditions), the hemostatic process is
activated, resulting in a fibrous, cellular-rich structure commonly referred to as a blood clot …

Abstract Human α2-antiplasmin (α2AP, also called α2-plasmin inhibitor) is the main
physiological inhibitor of the fibrinolytic enzyme plasmin. α2AP inhibits plasmin on the fibrin …

Alpha2-antiplasmin (α2AP), the fast-reacting, serine protease inhibitor (serpin) of plasmin,
was originally thought to play a key role in protection against uncontrolled, plasmin …

The formation and dissolution of blood clots is both a biochemical and a biomechanical
process. While much of the chemistry has been worked out for both processes, the influence …

Systemic sclerosis (SSc) is a connective tissue disease of autoimmune origin characterized
by vascular dysfunction and extensive fibrosis of the skin and visceral organs. Vascular …

Inhibitory serpins are metastable proteins that undergo a substantial conformational
rearrangement to covalently trap target peptidases. The serpin reactive center loop …

Chronic inflammatory diseases, such as rheumatoid arthritis, spondyloarthritis, systemic
lupus erythematosus, Crohn's disease, periodontitis, and carcinoma metastasis frequently …

Serpins form an enormous superfamily of 40–60-kDa proteins found in almost all types of
organisms, including humans. Most are one-use suicide substrate serine and cysteine …