Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …

While remarkable progress has recently been made for the direct C− H‐functionalization of
azines, its application is still limited by a lack of accessible functional groups (primarily …

The benzofuran core inhibitors HCV-796, BMS-929075, MK-8876, compound 2, and
compound 9B exhibit good pan-genotypic activity against various genotypes of NS5B …

The hepatitis C virus (HCV) NS5B replicase is a prime target for the development of direct-
acting antiviral drugs for the treatment of chronic HCV infection. Inspired by the overlay of …

Iterative structure–activity analyses in a class of highly functionalized furo [2, 3-b] pyridines
led to the identification of the second generation pan-genotypic hepatitis C virus NS5B …

Hepatitis C compromises the quality of life of more than 350 million individuals worldwide.
Over the last decade, therapeutic regimens for treating hepatitis C virus (HCV) infections …

Viruses are a real threat to every organism at any stage of life leading to extensive infections
and casualties. N-heterocycles can affect the viral life cycle at many points, including viral …

Due to its unique C–C and C–H bonding properties, conformational preferences and relative
hydrophilicity, the cyclopropyl ring has been used as a synthetic building block in drug …

Pyridine spirocycles play an important role in drug design and development. In this paper, a
novel spirocyclic cyclopentapyridine compound was synthesized. Based on retrosynthesis …

A concise 4-step synthesis of furo [2, 3-b] pyridines, with handles in the 3-and 5-positions for
palladium mediated cross-coupling reactions, is described. The synthetic route has been …