Application of the CRISPR/Cas9-based gene editing technique in basic research, diagnosis, and therapy of cancer

H Zhang, C Qin, C An, X Zheng, S Wen, W Chen, X Liu… - Molecular cancer, 2021 - Springer
Abstract The 2020 Nobel Prize in Chemistry was awarded to Emmanuelle Charpentier and
Jennifer Doudna for the development of the Clustered regularly interspaced short …

Pseudogene-derived lncRNAs and their miRNA sponging mechanism in human cancer

W Lou, B Ding, P Fu - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Pseudogenes, abundant in the human genome, are traditionally considered as non-
functional “junk genes.” However, recent studies have revealed that pseudogenes act as key …

Viral vectors and extracellular vesicles: innate delivery systems utilized in CRISPR/Cas-mediated cancer therapy

SE Ahmadi, M Soleymani, F Shahriyary… - Cancer Gene …, 2023 - nature.com
Gene editing-based therapeutic strategies grant the power to override cell machinery and
alter faulty genes contributing to disease development like cancer. Nowadays, the principal …

Exosomal lncRNA HMMR‐AS1 mediates macrophage polarization through miR‐147a/ARID3A axis under hypoxia and affects the progression of hepatocellular …

X Wang, Y Zhou, K Dong, H Zhang… - Environmental …, 2022 - Wiley Online Library
Background At present, the role of lncRNA in different kinds of tumors has been widely
reported, but its role with hypoxic environment and macrophage polarization is still unclear …

Upregulation of Superenhancer‐driven LncRNA FASRL by USF1 promotes de novo fatty acid biosynthesis to exacerbate hepatocellular carcinoma

JY Peng, DK Cai, RL Zeng, CY Zhang, GC Li… - Advanced …, 2023 - Wiley Online Library
Superenhancers drive abnormal gene expression in tumors and promote malignancy.
However, the relationship between superenhancer‐associated long noncoding RNA …

The role of non-coding RNAs in the diagnosis of different stages (HCC, CHB, OBI) of hepatitis B infection

O Gholizadeh, S Akbarzadeh, M Moein… - Microbial …, 2023 - Elsevier
Despite the availability of an effective hepatitis B virus (HBV) vaccine and universal
immunization schedules, HBV has remained a health problem in various stages such as …

[HTML][HTML] Mesenchymal stem cell-derived exosomes and non-coding RNAs: regulatory and therapeutic role in liver diseases

C Wang, H Zhou, R Wu, Y Guo, L Gong, K Fu… - Biomedicine & …, 2023 - Elsevier
Liver disease has become a major health problem worldwide due to its high morbidity and
mortality. In recent years, a large body of literature has shown that mesenchymal stem cell …

[HTML][HTML] Re-recognition of pseudogenes: From molecular to clinical applications

X Chen, L Wan, W Wang, WJ Xi, AG Yang, T Wang - Theranostics, 2020 - ncbi.nlm.nih.gov
Pseudogenes were initially regarded as “nonfunctional” genomic elements that did not have
protein-coding abilities due to several endogenous inactivating mutations. Although …

[HTML][HTML] Roles of long non-coding RNAs and emerging RNA-binding proteins in innate antiviral responses

Y Wang, Y Wang, W Luo, X Song, L Huang, J Xiao… - Theranostics, 2020 - ncbi.nlm.nih.gov
The diseases caused by viruses posed a great challenge to human health, the development
of which was driven by the imbalanced host immune response. Host innate immunity is an …

Functional long non-coding RNAs in hepatocellular carcinoma

C Xie, SY Li, JH Fang, Y Zhu, JE Yang - Cancer Letters, 2021 - Elsevier
Hepatocellular carcinoma (HCC) is a prevalent human malignancy with high morbidity
worldwide. Hepatocarcinogenesis is a complex multistep process, and its underlying …