A new and promising tool in membrane research is the detergent-free solubilization of
membrane proteins by styrene–maleic acid copolymers (SMAs). These amphipathic …

To study integral membrane proteins, one has to extract them from the membrane—the step
that is typically achieved by the application of detergents. In this mini-review, we summarize …

The proteins that form the permeation pathway of mechanosensory transduction channels in
inner-ear hair cells have not been definitively identified. Genetic, anatomical, and …

Transient receptor potential (TRP) channels are sensors for a wide range of cellular and
environmental signals, but elucidating how these channels respond to physical and …

The respiratory chain in the inner mitochondrial membrane contains three large multi‐
enzyme complexes that together establish the proton gradient for ATP synthesis, and …

Transient receptor potential (TRP) proteins form a superfamily Ca2+-permeable cation
channels regulated by a range of chemical and physical stimuli. Structural analysis of a …

A recent discovery in membrane research is the ability of styrene-maleic acid (SMA)
copolymers to solubilize membranes in the form of nanodisks allowing extraction and …

Abstract Structure determination of membrane proteins is critical to the molecular
understanding of many life processes, yet it has historically been a technically challenging …

Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …

Integral membrane proteins (IMPs) fulfill important physiological functions by providing cell–
environment, cell–cell and virus–host communication; nutrients intake; export of toxic …