Descriptive vs mechanistic scientific approach to study wound healing and its inhibition: Is there a value of translational research involving human subjects?

I Pastar, LL Wong, AN Egger… - Experimental …, 2018 - Wiley Online Library
The clinical field of wound healing is challenged by numerous hurdles. Not only are wound‐
healing disorders complex and multifactorial, but the corresponding patient population is …

[HTML][HTML] Metabolic reprogramming and reliance in human skin wound healing

M Manchanda, M Torres, F Inuossa, R Bansal… - Journal of Investigative …, 2023 - Elsevier
Impaired skin wound healing is a significant global health issue, especially among the
elderly. Wound healing is a well-orchestrated process involving the sequential phases of …

The High Impact of Staphylococcus aureus Biofilm Culture Medium on In Vitro Outcomes of Antimicrobial Activity of Wound Antiseptics and Antibiotic

J Paleczny, A Junka, M Brożyna, K Dydak… - Pathogens, 2021 - mdpi.com
The staphylococcal biofilm-based infections of wounds still pose a significant therapeutical
challenge. Treated improperly, they increase the risk of limb amputation or even death of the …

[HTML][HTML] A novel flow-system to establish experimental biofilms for modelling chronic wound infection and testing the efficacy of wound dressings

PF Duckworth, RS Rowlands, ME Barbour… - Microbiological …, 2018 - Elsevier
Several models exist for the study of chronic wound infection, but few combine all of the
necessary elements to allow high throughput, reproducible biofilm culture with the possibility …

各种组学分析在体表慢性难愈合创面中的研究进展

曾帅丹, 杨磊 - 中华烧伤与创面修复杂志, 2023 - zhsszz.xml-journal.net
体表慢性难愈合创面的诊断和治疗一直充满着挑战, 对医疗和社会造成巨大负担.
利用高通量测序技术结合组学分析可以揭示慢性创面形成的潜在机制, 识别与慢性创面诊断 …

Anaerobic bacteria in chronic wounds: Roles in disease, infection and treatment failure

A Coluccio, F Lopez Palomera… - Wound Repair and …, 2024 - Wiley Online Library
Infection is among the most common factors that impede wound healing, yet standard
treatments routinely fail to resolve chronic wound infections. The chronic wound …

The Medium Composition Impacts Staphylococcus aureus Biofilm Formation and Susceptibility to Antibiotics Applied in the Treatment of Bone Infections

J Paleczny, M Brożyna, R Dudek-Wicher… - International Journal of …, 2022 - mdpi.com
The biofilm-associated infections of bones are life-threatening diseases, requiring
application of dedicated antibiotics in order to counteract the tissue damage and spread of …

A microbiome and metabolomic signature of phases of cutaneous healing identified by profiling sequential acute wounds of human skin: An exploratory study

M Ashrafi, Y Xu, H Muhamadali, I White, M Wilkinson… - PLoS …, 2020 - journals.plos.org
Profiling skin microbiome and metabolome has been utilised to gain further insight into
wound healing processes. The aims of this multi-part temporal study in 11 volunteers were …

Microbial diversity of chronic wound and successful management of traditional chinese medicine

M Wu, Y Li, D Guo, G Kui, B Li… - Evidence‐Based …, 2018 - Wiley Online Library
Chronic ulcer, including diabetic ulcer, varicose ulcer, and pressure ulcer, negatively affects
patients' quality of life. As microbiology plays an important role in the mechanism of …

1H nuclear magnetic resonance spectroscopy reveals changes in metabolic phenotype associated with disease stage in patients with chronic venous disease

S Onida, HJ Lees, R Bergner, J Shalhoub… - European Journal of …, 2024 - Elsevier
Objective Chronic venous disease (CVD) is a condition presenting a great burden to
patients and society, with poorly characterised pathophysiology. Metabolic phenotyping can …