Learning Objectives Contrast the current strengths and limitations of the three main slide-
based techniques (IHC, FISH, and CISH) currently in clinical use for testing breast cancer …

The HER-2/neu oncogene encodes a transmembrane tyrosine kinase receptor with
extensive homology to the epidermal growth factor receptor. HER-2/neu has been widely …

Overexpression of ErbB2, a receptor-like tyrosine kinase, is shared by several types of
human carcinomas. In breast tumors the extent of overexpression has a prognostic value …

Abstract Learning Objectives After completing this course, the reader will be able to: Define
the historical background and biological basis of the discovery of the HER-2/neu gene and …

OBJECTIVE: To update the 1997 clinical practice guidelines for the use of tumor marker
tests in the prevention, screening, treatment, and surveillance of breast and colorectal …

The HER2 proto‐oncogene encodes a transmembrane glycoprotein of 185 kDa
(p185HER2) with intrinsic tyrosine kinase activity. Amplification of the HER2 gene and …

We reviewed the relationships between ERBB2 amplification and/or overexpression in
human breast cancer and the clinicopathological parameters described in the literature (97 …

The HER-2/neu oncogene, a member of the epidermal growth factor receptor or erb gene
family, encodes a transmembrane tyrosine kinase receptor that has been linked to prognosis …

PURPOSE: c-erbB-2 (HER-2, c-neu) might play a role as a predictive factor in breast cancer.
However, the clinical utility of the marker in this disease is still not established. We …

PURPOSE: To compare fluorescence in situ hybridization (FISH) and immunohistochemistry
(IHC) in the determination of HER-2/neu status of breast cancers. MATERIALS AND …