GABA A receptors are ligand-gated ion channels composed of five subunits that can be
opened by GABA and be modulated by multiple pharmacologically and clinically important …

Neurosteroids are endogenous modulators of neuronal excitability and nervous system
development and are being developed as anesthetic agents and treatments for psychiatric …

Alcohols and other anesthetic agents dramatically alter neurologic function in a wide range
of organisms, yet their molecular sites of action remain poorly characterized. Pentameric …

Pentameric ligand-gated ion channels control synaptic neurotransmission by converting
chemical signals into electrical signals. Agonist binding leads to rapid signal transduction …

Despite the clinical ubiquity of anesthesia, the molecular basis of anesthetic action is poorly
understood. Amongst the many molecular targets proposed to contribute to anesthetic …

Pentameric ligand-gated ion channels (pLGICs), such as nicotinic acetylcholine, glycine, γ-
aminobutyric acid GABA A/C receptors, and the Gloeobacter violaceus ligand-gated ion …

Although general anesthetics are known to modulate the activity of ligand-gated ion
channels in the Cys-loop superfamily, there is at present neither consensus on the …

The cellular membrane constitutes the first element that encounters a wide variety of
molecular species to which a cell might be exposed. Hosting a large number of structurally …

The anesthetic propofol inhibits the currents of the homopentameric ligand-gated ion
channel GLIC, yet the crystal structure of GLIC with five propofol molecules bound …

Ligand-gated ion channels conduct currents in response to chemical stimuli, mediating
electrochemical signaling in neurons and other excitable cells. For many channels, the …