A single protein-rich meal (or an infusion of amino acids) is known to increase the
glomerular filtration rate (GFR) for a few hours, a phenomenon known as “hyperfiltration.” It …

Diuretics are the first-line therapy for widespread cardiovascular and non-cardiovascular
diseases. Traditional diuretics are commonly prescribed for treatment in patients with …

Background & Aims Constipation is a common clinical problem that negatively impacts
quality of life and is associated with significant health care costs. Activation of the cystic …

Urea's transmembrane transport through urea transporters (UT) is a fundamental
physiological behavior for life activities. Here, we present 11 cryo-EM structures of four UT …

In this study, in vivo T2 heterogeneity of hyperpolarized [13C, 15N2] urea in rat kidney has
been investigated. Selective quenching of the vascular hyperpolarized 13C signal with a …

Dry eye disorders, including Sjögren's syndrome, constitute a common problem in the aging
population, with limited effective therapeutic options available. The cAMP-activated Cl …

Vasopressin (AVP) and its receptors play a pivotal role in maintaining body homeostasis
under physiological and pathophysiological conditions. As a consequence, the vasopressin …

Conventional diuretics such as furosemide and thiazides target salt transporters in kidney
tubules, but urea transporters (UTs) have emerged as alternative targets. UTs are a family of …

Urea transporter A (UT-A) isoforms encoded by the Slc14a2 gene are expressed in kidney
tubule epithelial cells, where they facilitate urinary concentration. UT-A1 inhibition is …

Urea transport and clinical potential of urearetics : Current Opinion in Nephrology and
Hypertension Urea transport and clinical potential of urearetics : Current Opinion in Nephrology …