EMT and inflammation: inseparable actors of cancer progression

M Suarez‐Carmona, J Lesage, D Cataldo… - Molecular …, 2017 - Wiley Online Library
Tumors can be depicted as wounds that never heal, and are infiltrated by a large array of
inflammatory and immune cells. Tumor‐associated chronic inflammation is a hallmark of …

Pharmacological activities of psoralidin: a comprehensive review of the molecular mechanisms of action

J Sharifi-Rad, S Kamiloglu, B Yeskaliyeva… - Frontiers in …, 2020 - frontiersin.org
Analysis of the most relevant studies on the pharmacological properties and molecular
mechanisms of psoralidin, a bioactive compound from the seeds of Cullen corylifolium (L.) …

Identification of a novel glycolysis-related gene signature for predicting metastasis and survival in patients with lung adenocarcinoma

L Zhang, Z Zhang, Z Yu - Journal of translational medicine, 2019 - Springer
Background Lung cancer (LC) is one of the most lethal and most prevalent malignant
tumors, and its incidence and mortality are increasing annually. Lung adenocarcinoma …

Inhibition of AKT promotes FOXO3a-dependent apoptosis in prostate cancer

TP Das, S Suman, H Alatassi, MK Ankem… - Cell death & …, 2016 - nature.com
Growth factor-induced activation of protein kinase-B (PKB), also known as AKT, induces pro-
survival signaling and inhibits activation of pro-apoptotic signaling molecules including the …

Silencing NOTCH signaling causes growth arrest in both breast cancer stem cells and breast cancer cells

S Suman, TP Das, C Damodaran - British journal of cancer, 2013 - nature.com
Background: Breast cancer stem cells (BCSCs) are characterized by high aldehyde
dehydrogenase (ALDH) enzyme activity and are refractory to current treatment modalities …

[HTML][HTML] Oxidative stress mediates the conversion of endothelial cells into myofibroblasts via a TGF-β1 and TGF-β2-dependent pathway

I Montorfano, A Becerra, R Cerro, C Echeverría… - Laboratory …, 2014 - Elsevier
During the pathogenesis of systemic inflammation, reactive oxygen species (ROS) circulate
in the bloodstream and interact with endothelial cells (ECs), increasing intracellular …

ZnO nanoparticles treatment induces apoptosis by increasing intracellular ROS levels in LTEP‐a‐2 cells

C Wang, X Hu, Y Gao, Y Ji - BioMed research international, 2015 - Wiley Online Library
Owing to the wide use of novel nanoparticles (NPs) such as zinc oxide (ZnO) in all aspects
of life, toxicological research on ZnO NPs is receiving increasing attention in these days. In …

Stevia rebaudiana Methanolic Leaf Extract in Egypt: Phytochemical Analysis, Antioxidant, Antilipid Peroxidation, Antihemolytic, Antimetastatic, and Anticancer …

DH Hanna, R Osailan… - Journal of Food …, 2023 - Wiley Online Library
The phenolic and flavonoid content of the Stevia rebaudiana hydromethanolic extract
(SRHME) was examined, and phytochemical identification using GC‐mass spectrometry …

Withaferin A, a Steroidal Lactone from Withania somnifera, Induces Mitotic Catastrophe and Growth Arrest in Prostate Cancer Cells

RV Roy, S Suman, TP Das, JE Luevano… - Journal of natural …, 2013 - ACS Publications
Cell cycle deregulation is strongly associated with the pathogenesis of prostate cancer.
Clinical trials of cell cycle regulators that target either the G0/G1 or G2/M phase to inhibit the …

Sinomenine confers protection against myocardial ischemia reperfusion injury by preventing oxidative stress, cellular apoptosis, and inflammation

B Xia, Q Li, J Wu, X Yuan, F Wang, X Lu… - Frontiers in …, 2022 - frontiersin.org
Sinomenine (SIN), an alkaloid extracted from the root of S. acutum. sinomenine, has been
shown to have antiarrhythmic, antioxidant, and anti-inflammatory effects in myocardial …