Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

Thiazole, a unique heterocycle containing sulphur and nitrogen atoms, occupies an
important place in medicinal chemistry. It is an essential core scaffold present in many …

Background The link between DNA methylation, obesity, and adiposity-related diseases in
the general population remains uncertain. Methods and Findings We conducted an …

There is a constant high demand for energy to sustain the continuous contractile activity of
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …

Cardiac ischemia and its consequences including heart failure, which itself has emerged as
the leading cause of morbidity and mortality in developed countries are accompanied by …

Malonyl-CoA can be formed within the mitochondria, peroxisomes, and cytosol of
mammalian cells. Besides being an intermediate in the pathways of de novo fatty acid …

Type 2 diabetes mellitus (T2DM)-induced cardiomyopathy is associated with cardiac
oxidative stress, inflammation, and remodeling. Sulforaphane (SFN), an isothiocyanate …

The incidence of diabetes is increasing globally, with cardiovascular disease accounting for
a substantial number of diabetes-related deaths. Although atherosclerotic vascular disease …

Metabolic cardiomyopathy is an emerging cause of heart failure in patients with obesity,
insulin resistance, and diabetes. It is characterized by impaired myocardial metabolic …

The AMP-activated protein kinase (AMPK) is an αβγ heterotrimer that regulates appetite and
fuel metabolism. We have generated AMPK β1−/− mice on a C57Bl/6 background that are …