AMPK is an important kinase regulating energy homeostasis and also a key protein involved
in a variety of signal transduction pathways. It plays a vitally regulatory role in cellular …

Metformin is a biguanide drug widely used as the initial treatment of type 2 diabetes. Despite
its widespread use, its precise mechanisms of action remain incompletely characterised. Its …

This study was conducted to estimate the protective effect of Cyanidin‐3‐glucoside (C3G) on
myocardial ischemia‐reperfusion (IR) injury and to explore its mechanism. The rats were …

Background Silicosis is one of the most common occupational pulmonary fibrosis caused by
respirable silica-based particle exposure, with no ideal drugs at present. Metformin, a …

Type 2 diabetes mellitus (T2DM) is a worldwide major health burden and heart failure (HF)
is the most common cardiovascular (CV) complication in affected patients. Therefore …

Heart failure is one of the leading causes of death and disability worldwide. Left ventricle
remodeling, fibrosis, and ischemia/reperfusion injury all contribute to the deterioration of …

As an intracellular polyprotein complex, the NLRP3 inflammasome is activated by NLRP3
perceiving pathogen-related molecular patterns, damage-related molecular patterns …

Cardiovascular diseases (CVDs) are serious public health issues and are responsible for
nearly one-third of global deaths. Mitochondrial dysfunction is accountable for the …

Emerging evidence indicates that the enhancement of microglial autophagy inhibits the
NLRP3 inflammasome mediated neuroinflammation in Alzheimer's disease (AD) …

Background Although the development of therapies for heart failure (HF) continues apace,
clinical outcomes are often far from ideal. Unc51-like-kinase 1 (ULK1)-mediated mitophagy …