Synthesis of heterocyclic compounds via Michael and Hantzsch reactions

AM Abdella, AM Abdelmoniem… - Journal of …, 2020 - Wiley Online Library
Heterocycles represent the largest diversity of organic compounds with signifcant chemical,
biomedical, and industrial applications. They exist in numerous natural products, dyes, and …

Heterocyclization reactions using malononitrile dimer (2-aminopropene-1, 1, 3-tricarbonitrile)

VV Dotsenko, SG Krivokolysko… - Chemistry of Heterocyclic …, 2018 - Springer
In this work, we provide the first generalized and critical analysis of data on the chemistry of
malononitrile dimer (2-aminopropene-1, 1, 3-tricarbonitrile)–a multifunctional reagent that is …

One-pot synthesis of novel poly-substituted 3-cyanopyridines: Molecular docking, antimicrobial, cytotoxicity, and DFT/TD-DFT studies

IM Abdellah, MR Eletmany, AA Abdelhamid… - Journal of Molecular …, 2023 - Elsevier
Abstract Novel pyridine-3-carbonitrile derivatives, denoted as (4a-j), were synthesized using
a convergent synthetic approach that involved a one-pot four-component reaction. This was …

Multicomponent design of chromeno [2, 3-b] pyridine systems

MN Elinson, YE Ryzhkova… - Russian Chemical …, 2021 - iopscience.iop.org
The review summarizes and systematizes data on the methods for the preparation of
chromeno [2, 3-b] pyridines. Both multicomponent and pseudo-multicomponent synthetic …

Facile synthesis and antimicrobial activity of bis(fused 4H‐pyrans) incorporating piperazine as novel hybrid molecules: Michael's addition approach

ME Salem, IMZ Fares, SAS Ghozlan… - Journal of …, 2022 - Wiley Online Library
A new series of bis (4 H‐chromene), bis (pyrano [3, 2‐c] chromene), and bis (pyrano [2, 3‐c]
pyrazole) each linked to the piperazine core via ether linkages was synthesized. The target …

Malononitrile dimer as a privileged reactant in design and skeletal diverse synthesis of heterocyclic motifs

A Shaabani, SE Hooshmand - Molecular diversity, 2018 - Springer
Malononitrile dimer as a precursor reactant has been extensively applied in the diversity-
oriented synthesis of various heterocyclic motifs, bis-heterocyclic compounds, fused …

Hantzsch-like one-pot three-component synthesis of heptaazadicyclopenta [a, j] anthracenes: a new ring system

AM Abdelmoniem, FM Sroor, MA Ramadan… - Synlett, 2020 - thieme-connect.com
A concise and efficient approach to novel tetrahydroheptaazadicyclopenta [a, j] anthracene-
5, 7-diones, by the reaction of aldehydes with two moles of 7-amino-2-methyl-3 …

[PDF][PDF] Synthesis and DFT studies of novel aminoimidazodipyridines using 2-(3H-imidazo [4, 5-b] pyrid-2-yl) acetonitrile as an efficient key precursor.

AF Darweesh, NAA El-Fatah… - … : Online Journal of …, 2021 - pdfs.semanticscholar.org
Abstract Novel 9-aminoimidazo [1, 2-a: 5, 4-b'] dipyridine-6, 8-dicarbonitriles were prepared
via the Michael addition reaction of readily accessible 2-(3H-imidazo [4, 5-b] pyrid-2-yl) …

Hantzsch one-pot multicomponent synthesis of a novel series of bis(9,10-diarylhexahydroacridine-1,8-diones)

AM Abdelmoniem, HF Hammad… - Synthetic …, 2021 - Taylor & Francis
Efficient procedures have been developed for the synthesis of novel series of bis (9, 10-
diaryl-hexahydroacridine-1, 8-diones) in which the two acridine moieties were linked to …

Synthesis of novel scaffolds based on thiazole or triazolothiadiazine linked to benzofuran or benzo[d]thiazole moieties as new hybrid molecules

ME Salem, AF Darweesh… - Synthetic Communications, 2020 - Taylor & Francis
A synthesis of novel hybrid molecules containing thiazole or bis (thiazoles) each bearing
benzofuran and/or benzo [d] thiazole moieties by the reaction of the appropriate thioamide …