It is increasingly clear that academic high-throughput screening (HTS) and virtual HTS triage
suffers from a lack of scientists trained in the art and science of early drug discovery …

Technological advances have made it feasible to conduct high-throughput small-molecule
screens based on visual phenotypes of individual cells, using automated imaging and …

Repurposing and repositioning drugs—discovering new uses for existing and experimental
medicines—is an attractive strategy for rescuing stalled pharmaceutical projects, finding …

High-throughput screening (HTS) can efficiently assay multiple discrete biological reactions
using multi-well microplates. The choice of microplate is a crucial yet often overlooked …

Introduction Natural hair curvature and colour are genetically determined human traits, that
we intentionally change by applying thermal and chemical treatments to the fibre. Presently …

High content imaging produces significant volumes of data on individual cells. The number
of discrete measurements per cell can be in the thousands for highly multiplexed assays …

Background: Drug discovery is the process of discovering and designing drugs, which
includes target identification, target validation, lead identification, lead optimization and …

Significant efforts have been made recently to improve data throughput and data quality in
screening technologies related to drug design. The modern pharmaceutical industry relies …

Motivation: High-throughput screening (HTS) is an early-stage process in drug discovery
which allows thousands of chemical compounds to be tested in a single study. We report a …

The molecular mechanisms controlling mouse embryonic stem cell (ESC) metastability, ie
their capacity to fluctuate between different states of pluripotency, are not fully resolved. We …