Cell signaling plays a key role in the development of all multicellular organisms. Numerous
studies have established the importance of Hedgehog signaling in a wide variety of …

The basic vertebrate body plan of the zebrafish embryo is established in the first 10 hours of
development. This period is characterized by the formation of the anterior-posterior and …

In a large-scale screen, we isolated mutants displaying a specific visible phenotype in
embryos or early larvae of the zebrafish, Danio rerio. Males were mutagenized with …

Zebrafish embryos and larvae have stage-specific patterns of motility or locomotion. Two
embryonic structures accomplish this behavior: the central nervous system (CNS) and …

The zebrafish pronephric kidney provides a simplified model of nephron development and
epithelial cell differentiation which is amenable to genetic analysis. The pronephros consists …

Neural crest development involves cell-fate specification, proliferation, patterned cell
migration, survival and differentiation. Zebrafish neural crest derivatives include three …

Defects in cerebrospinal fluid (CSF) flow may contribute to idiopathic scoliosis. However, the
mechanisms underlying detection of CSF flow in the central canal of the spinal cord are …

Cilia are essential for fertilization, respiratory clearance, cerebrospinal fluid circulation and
establishing laterality. Cilia motility defects cause primary ciliary dyskinesia (PCD …

The head is anatomically the most sophisticated part of the body and its evolution was
fundamental to the origin of vertebrates; understanding its development is a formidable …

Somitogenesis is the basis of segmentation of the mesoderm in the trunk and tail of
vertebrate embryos. Two groups of mutants with defects in this patterning process have …