Simple Summary The present review highlights and examines the importance of animal
models in relevant topics concerning current human and animal health. Over the past five …

Animal models are fundamental to advance our knowledge of the underlying
pathophysiology of bone loss and to study pharmaceutical countermeasures against it. The …

Current biomedical models fail to replicate the complexity of human biology. Consequently,
almost 90% of drug candidates fail during clinical trials after decades of research and …

Nitric oxide (NO) is a small molecule that plays important roles in biological systems and
human diseases. The abundance of intracellular NO is tightly related to numerous biological …

Nanomedicine plays an essential role in developing new therapies through novel drug
delivery systems, diagnostic and imaging systems, vaccine development, antibacterial tools …

Recent development of human three-dimensional organoid cultures has opened new doors
and opportunities ranging from modelling human development in vitro to personalised …

Science has been taking profit from animal models since the first translational experiments
back in ancient Greece. From there, and across all history, several remarkable findings have …

Candida auris emerges as an important causative agent of fungal infections, with worrisome
mortality rates, mainly in immunocompromised individuals. This scenario is worsened by the …

This work sought to develop a robust and clinically relevant swine model of critical limb
ischemia (CLI) involving the onset of ischemic muscle necrosis. CLI carries about 25–40 …

Cancer is one of the most important public health problems worldwide. Despite the great
contribution of in-vitro studies for biomedical research, animals are essential to study …