The two sides of chromosomal instability: drivers and brakes in cancer
R Hosea, S Hillary, S Naqvi, S Wu… - Signal Transduction and …, 2024 - nature.com
Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …
Permission to pass: on the role of p53 as a gatekeeper for aneuploidy
JF Marques, GJPL Kops - Chromosome Research, 2023 - Springer
Aneuploidy—the karyotype state in which the number of chromosomes deviates from a
multiple of the haploid chromosome set—is common in cancer, where it is thought to …
multiple of the haploid chromosome set—is common in cancer, where it is thought to …
Genomic alterations driving precancerous to cancerous lesions in esophageal cancer development
Esophageal squamous cell carcinoma (ESCC) develops through a series of increasingly
abnormal precancerous lesions. Previous studies have revealed the striking differences …
abnormal precancerous lesions. Previous studies have revealed the striking differences …
Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus
Oncogenic PIK3CA mutations generate large clones in aging human esophagus. Here we
investigate the behavior of Pik3ca mutant clones in the normal esophageal epithelium of …
investigate the behavior of Pik3ca mutant clones in the normal esophageal epithelium of …
[HTML][HTML] Self-sustaining long-term 3D epithelioid cultures reveal drivers of clonal expansion in esophageal epithelium
Aging epithelia are colonized by somatic mutations, which are subjected to selection
influenced by intrinsic and extrinsic factors. The lack of suitable culture systems has slowed …
influenced by intrinsic and extrinsic factors. The lack of suitable culture systems has slowed …
Differential squamous cell fates elicited by NRF2 gain of function versus KEAP1 loss of function
J Takahashi, T Suzuki, M Sato, S Nitta, N Yaguchi… - Cell Reports, 2024 - cell.com
Clinical evidence has revealed that high-level activation of NRF2 caused by somatic
mutations in NRF2 (NFE2L2) is frequently detected in esophageal squamous cell carcinoma …
mutations in NRF2 (NFE2L2) is frequently detected in esophageal squamous cell carcinoma …
Early development of esophageal squamous cell cancer: Stem cells, cellular origins and early clone evolution
G Liao, J Tang, J Bai - Cancer Letters, 2023 - Elsevier
Esophageal squamous cell carcinoma (ESCC), a highly malignant cancer with poor
prognosis, is an example of the classical view of cancer development based on stem cell …
prognosis, is an example of the classical view of cancer development based on stem cell …
Somatic mutations in normal tissues: new perspectives on early carcinogenesis
Normal tissues progressively acquire mutations. Some mutations are positively selected,
driving clonal expansions that may colonize the majority of a tissue by old age. In several …
driving clonal expansions that may colonize the majority of a tissue by old age. In several …
The TP53 Codon 72 Arginine Polymorphism Is Found with Increased TP53 Somatic Mutations in HPV(−) and in an Increased Percentage among HPV(+) Norwegian …
SE Moe, FA Erland, S Fromreide, S Lybak, M Brydoy… - Biomedicines, 2023 - mdpi.com
Background: Somatic TP53 mutations are frequent in head and neck squamous cell
carcinoma (HNSCC) and are important pathogenic factors. Objective: To study TP53 …
carcinoma (HNSCC) and are important pathogenic factors. Objective: To study TP53 …
Multimodal analysis of cfDNA methylomes for early detecting esophageal squamous cell carcinoma and precancerous lesions
Detecting early-stage esophageal squamous cell carcinoma (ESCC) and precancerous
lesions is critical for improving survival. Here, we conduct whole-genome bisulfite …
lesions is critical for improving survival. Here, we conduct whole-genome bisulfite …