Gold nanoparticles as radiosensitizers in cancer radiotherapy

Y Chen, J Yang, S Fu, J Wu - International Journal of …, 2020 - Taylor & Francis
The rapid development of nanotechnology offers a variety of potential therapeutic strategies
for cancer treatment. High atomic element nanomaterials are often utilized as …

[HTML][HTML] Nanoparticles for radiation therapy enhancement: the key parameters

P Retif, S Pinel, M Toussaint, C Frochot, R Chouikrat… - Theranostics, 2015 - ncbi.nlm.nih.gov
This review focuses on the radiosensitization strategies that use high-Z nanoparticles. It
does not establish an exhaustive list of the works in this field but rather propose constructive …

Radiosensitization by gold nanoparticles: Will they ever make it to the clinic?

L Cui, S Her, GR Borst, RG Bristow, DA Jaffray… - Radiotherapy and …, 2017 - Elsevier
The utilization of gold nanoparticles (AuNPs) as radiosensitizers has shown great promise in
pre-clinical research. In the current review, the physical, chemical, and biological pathways …

[HTML][HTML] Standards and methodologies for characterizing radiobiological impact of high-Z nanoparticles

A Subiel, R Ashmore, G Schettino - Theranostics, 2016 - ncbi.nlm.nih.gov
Research on the application of high-Z nanoparticles (NPs) in cancer treatment and
diagnosis has recently been the subject of growing interest, with much promise being shown …

NBTXR3 radiotherapy-activated functionalized hafnium oxide nanoparticles show efficient antitumor effects across a large panel of human cancer models

P Zhang, J Marill, A Darmon… - International Journal …, 2021 - Taylor & Francis
Purpose The side effects of radiotherapy induced on healthy tissue limit its use. To
overcome this issue and fully exploit the potential of radiotherapy to treat cancers, the first-in …

Simulations of dose enhancement for heavy atom nanoparticles irradiated by protons

C Wälzlein, E Scifoni, M Krämer… - Physics in Medicine & …, 2014 - iopscience.iop.org
A possible dose enhancement effect by proton or electron irradiation in the vicinity of
nanoparticles consisting of different high Z atomic materials has been investigated using the …

Geant4‐DNA track‐structure simulations for gold nanoparticles: the importance of electron discrete models in nanometer volumes

D Sakata, I Kyriakou, S Okada, HN Tran… - Medical …, 2018 - Wiley Online Library
Purpose Gold nanoparticles (GNPs) are known to enhance the absorbed dose in their
vicinity following photon‐based irradiation. To investigate the therapeutic effectiveness of …

Evaluation of size, morphology, concentration, and surface effect of gold nanoparticles on X-ray attenuation in computed tomography

S Khademi, S Sarkar, S Kharrazi, SM Amini… - Physica Medica, 2018 - Elsevier
Increasing attention has been focused on the use of nanostructures as contrast
enhancement agents in medical imaging, especially in computed tomography (CT). To date …

Nanoscale radiation transport and clinical beam modeling for gold nanoparticle dose enhanced radiotherapy (GNPT) using X-rays

P Zygmanski, E Sajo - The British journal of radiology, 2016 - academic.oup.com
We review radiation transport and clinical beam modelling for gold nanoparticle dose-
enhanced radiotherapy using X-rays. We focus on the nanoscale radiation transport and its …

A review of recent advances in the modeling of nanoparticle radiosensitization with the Geant4-DNA toolkit

A Taheri, MU Khandaker, F Moradi… - Radiation Physics and …, 2023 - Elsevier
Metallic nanoparticles are promising agents for increasing the effectiveness of radiation
therapy by making cells more sensitive to radiation. High atomic number nanoparticles …