Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
V Janssens, J Goris - Biochemical Journal, 2001 - portlandpress.com
Protein phosphatase 2A (PP2A) comprises a family of serine/threonine phosphatases,
minimally containing a well conserved catalytic subunit, the activity of which is highly …
minimally containing a well conserved catalytic subunit, the activity of which is highly …
RNA and protein interactions modulated by protein arginine methylation
JD Gary, S Clarke - Progress in nucleic acid research and molecular …, 1998 - Elsevier
This review summarizes the current status of protein arginine N-methylation reactions.
These covalent modifications of proteins are now recognized in a number of eukaryotic …
These covalent modifications of proteins are now recognized in a number of eukaryotic …
Role of translocation in the activation and function of protein kinase B
M Andjelkovic, DR Alessi, R Meier, A Fernandez… - Journal of Biological …, 1997 - ASBMB
We have investigated the role of subcellular localization in the regulation of protein kinase B
(PKB) activation. The myristoylation/palmitylation motif from the Lck tyrosine kinase was …
(PKB) activation. The myristoylation/palmitylation motif from the Lck tyrosine kinase was …
γ-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair
Phosphorylated histone H2AX (γ-H2AX) forms foci over large chromatin domains
surrounding double-stranded DNA breaks (DSB). These foci recruit DSB repair proteins and …
surrounding double-stranded DNA breaks (DSB). These foci recruit DSB repair proteins and …
Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme
Abstract Protein phosphatase 2A (PP2A) is a principal Ser/Thr phosphatase, the
deregulation of which is associated with multiple human cancers, Alzheimer's disease and …
deregulation of which is associated with multiple human cancers, Alzheimer's disease and …
The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase
WJ Lin, JD Gary, MC Yang, S Clarke… - Journal of Biological …, 1996 - ASBMB
The TIS21 immediate-early gene and leukemia-associated BTG1 gene encode proteins with
similar sequences. Two-hybrid analysis identified a protein that interacts with TIS21 and …
similar sequences. Two-hybrid analysis identified a protein that interacts with TIS21 and …
[HTML][HTML] Surf the post-translational modification network of p53 regulation
Among the human genome, p53 is one of the first tumor suppressor genes to be discovered.
It has a wide range of functions covering cell cycle control, apoptosis, genome integrity …
It has a wide range of functions covering cell cycle control, apoptosis, genome integrity …
Serine/threonine protein phosphatases.
S Wera, BA Hemmings - Biochemical Journal, 1995 - ncbi.nlm.nih.gov
INTRODUCTION Phosphorylation of structural and regulatory proteins is a major
intracellular control mechanism in eukaryotes. The phosphoryl-ation state of a protein is a …
intracellular control mechanism in eukaryotes. The phosphoryl-ation state of a protein is a …
Identification of specific PP2A complexes involved in human cell transformation
W Chen, R Possemato, KT Campbell, CA Plattner… - Cancer cell, 2004 - cell.com
The SV40 small t antigen (ST) interacts with the serine-threonine protein phosphatase 2A
(PP2A). To investigate the role of this interaction in transformation, we suppressed the …
(PP2A). To investigate the role of this interaction in transformation, we suppressed the …
The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and …
B McCright, AM Rivers, S Audlin, DM Virshup - Journal of Biological …, 1996 - ASBMB
Protein phosphatase 2A is a heterotrimeric protein serine/threonine phosphatase consisting
of a 36-kDa catalytic C subunit, a 65-kDa structural A subunit, and a variable regulatory B …
of a 36-kDa catalytic C subunit, a 65-kDa structural A subunit, and a variable regulatory B …