[HTML][HTML] Lipid alterations in chronic liver disease and liver cancer

B Paul, M Lewinska, JB Andersen - JHEP reports, 2022 - Elsevier
Lipids are a complex and diverse group of molecules with crucial roles in many
physiological processes, as well as in the onset, progression, and maintenance of cancers …

Dietary carbohydrates and fats in nonalcoholic fatty liver disease

H Yki-Järvinen, PK Luukkonen, L Hodson… - Nature reviews …, 2021 - nature.com
The global prevalence of nonalcoholic fatty liver disease (NAFLD) has dramatically
increased in parallel with the epidemic of obesity. Controversy has emerged around dietary …

The liver as an endocrine organ—linking NAFLD and insulin resistance

MJ Watt, PM Miotto, W De Nardo… - Endocrine …, 2019 - academic.oup.com
The liver is a dynamic organ that plays critical roles in many physiological processes,
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …

Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance

RCR Meex, MJ Watt - Nature Reviews Endocrinology, 2017 - nature.com
Hepatic steatosis is an underlying feature of nonalcoholic fatty liver disease (NAFLD), which
is the most common form of liver disease and is present in up to∼ 70% of individuals who …

Understanding the mechanisms of reversal of type 2 diabetes

R Taylor, A Al-Mrabeh, N Sattar - The lancet Diabetes & …, 2019 - thelancet.com
Clinical and pathophysiological studies have shown type 2 diabetes to be a condition mainly
caused by excess, yet reversible, fat accumulation in the liver and pancreas. Within the liver …

It is high time physicians thought of natural products for alleviating NAFLD. Is there sufficient evidence to use them?

G Tarantino, C Balsano, SJ Santini, G Brienza… - International journal of …, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most common form of liver disease all over
the world due to the obesity pandemic; currently, therapeutic options for NAFLD are scarce …

Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome

H Yki-Järvinen - The lancet Diabetes & endocrinology, 2014 - thelancet.com
Metabolic syndrome is a cluster of metabolic abnormalities that identifies people at risk of
diabetes and cardiovascular disease, whereas non-alcoholic fatty liver disease (NAFLD) is …

Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver

P Dongiovanni, S Stender, A Pietrelli… - Journal of internal …, 2018 - Wiley Online Library
Abstract Background and Aims Nonalcoholic fatty liver disease is epidemiologically
associated with hepatic and metabolic disorders. The aim of this study was to examine …

Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease

PK Luukkonen, S Dufour, K Lyu… - Proceedings of the …, 2020 - National Acad Sciences
Weight loss by ketogenic diet (KD) has gained popularity in management of nonalcoholic
fatty liver disease (NAFLD). KD rapidly reverses NAFLD and insulin resistance despite …

Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease

PK Luukkonen, Y Zhou, S Sädevirta, M Leivonen… - Journal of …, 2016 - Elsevier
Background & Aims Recent data in mice have identified de novo ceramide synthesis as the
key mediator of hepatic insulin resistance (IR) that in humans characterizes increases in …