Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a
major cause of morbidity and mortality. The circadian timing system consists of a central …

Humans live in a 24-hour environment, in which light and darkness follow a diurnal pattern.
Our circadian pacemaker, the suprachiasmatic nuclei (SCN) in the hypothalamus, is …

Ocular light exposure has important influences on human health and well-being through
modulation of circadian rhythms and sleep, as well as neuroendocrine and cognitive …

Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however,
circadian rhythm disruptions are more severe in people with age-related neurodegenerative …

Many processes in the human body—including brain function—are regulated over the 24-
hour cycle, and there are strong associations between disrupted circadian rhythms (for …

Executive summary Acting now on dementia prevention, intervention, and care will vastly
improve living and dying for individuals with dementia and their families, and in doing so …

Background: Insomnia remains one of the most common sleep disorders encountered in the
geriatric clinic population, frequently characterized by the subjective complaint of difficulty …

Epidemiological studies provided the first evidence suggesting a connection between the
circadian clock and human health. Mutant mice convincingly demonstrate the principle that …

Disruptions of normal circadian rhythms and sleep cycles are consequences of aging and
can profoundly affect health. Accumulating evidence indicates that circadian and sleep …

Daylight is ubiquitous and is crucial for mammalian vision as well as for non-visual input to
the brain via the intrinsically photosensitive retinal ganglion cells (ipRGCs) that express the …