Klebsiella Pneumoniae: An Update on Antibiotic Resistance Mechanisms

M Karami-Zarandi, HA Rahdar, H Esmaeili… - Future …, 2023 - Taylor & Francis
Klebsiella pneumoniae colonizes mucosal surfaces of healthy humans and is responsible
for one third of all Gram-negative infections in hospitalized patients. K. pneumoniae is …

The role of adjuvants in overcoming antibacterial resistance due to enzymatic drug modification

C El-Khoury, E Mansour, Y Yuliandra, F Lai… - RSC Medicinal …, 2022 - pubs.rsc.org
Antibacterial resistance is a prominent issue with monotherapy often leading to treatment
failure in serious infections. Many mechanisms can lead to antibacterial resistance including …

Aminoglycoside-resistance gene signatures are predictive of aminoglycoside MICs for carbapenem-resistant Klebsiella pneumoniae

Y Huang, AP Rana, E Wenzler, EA Ozer… - Journal of …, 2022 - academic.oup.com
Background Aminoglycoside-containing regimens may be an effective treatment option for
infections caused by carbapenem-resistant Klebsiella pneumoniae (CR-Kp), but …

Mechanisms of Antibiotic Resistance and Developments in Therapeutic Strategies to Combat Klebsiella pneumoniae Infection

Y Li, S Kumar, L Zhang - Infection and Drug Resistance, 2024 - Taylor & Francis
Infections with drug-resistant bacteria have become one of the greatest public health
challenges, and K. pneumoniae is among the top six drug-resistant bacteria. K. pneumoniae …

Genomic Investigation of Carbapenem-Resistant Klebsiella pneumonia Colonization in an Intensive Care Unit in South Africa

O Madni, DG Amoako, ALK Abia, J Rout, SY Essack - Genes, 2021 - mdpi.com
The study investigated carbapenemase-producing Klebsiella pneumoniae (CPKP) isolates
of patients in an intensive care unit (ICU) in a public hospital in the KwaZulu-Natal province …

Combatting Planktonic and Biofilm Populations of Carbapenem-Resistant Acinetobacter baumannii with Polymyxin-Based Combinations

M Wences, ER Wolf, C Li, N Singh, N Bah, X Tan… - Antibiotics, 2022 - mdpi.com
Carbapenem-resistant Acinetobacter baumannii (CRAB) can cause serious infections that
are associated with high mortality rates. During the course of an infection, many CRAB …

Generating Genotype-Specific Aminoglycoside Combinations with Ceftazidime/Avibactam for KPC-Producing Klebsiella pneumoniae

Y Huang, K Sokolowski, A Rana, N Singh… - Antimicrobial agents …, 2021 - Am Soc Microbiol
Antibiotic combinations, including ceftazidime/avibactam (CAZ/AVI), are frequently
employed to combat KPC-producing Klebsiella pneumoniae (KPC-Kp), though such …

[HTML][HTML] Ceftazidime/avibactam alone or in combination with an aminoglycoside for treatment of carbapenem-resistant Enterobacterales infections: A retrospective …

ZP Bulman, L Cao, BN Curry, M Biagi, A Vivo… - International journal of …, 2024 - Elsevier
Background Ceftazidime/avibactam is one of the preferred treatment options for
carbapenem-resistant Enterobacterales (CRE). However, the benefit of combining …

Long Term Characteristics of Clinical Distribution and Resistance Trends of Carbapenem-Resistant and Extended-Spectrum β-Lactamase Klebsiella pneumoniae …

N Wang, M Zhan, T Wang, J Liu, C Li, B Li… - Infection and drug …, 2023 - Taylor & Francis
Purpose Through long-term and large sample size statistical analysis, we revealed the
pattern of Klebsiella pneumoniae (KP) infection and drug resistance and provided …

Characterization of aminoglycoside-resistant Enterobacteriaceae isolated from inanimate hospital surfaces in Egypt

AH Fahmy, KA El-Dogdog… - Egyptian Journal of …, 2024 - journals.ekb.eg
Background: The emergence of antibiotic resistance is one of the major issues facing global
healthcare systems. Objectives: This study aims to determine the prevalence and resistance …