New approaches to target antibacterial agents toward Gram-negative bacteria are key, given
the rise of antibiotic resistance. Since the discovery of polymyxin B nonapeptide as a potent …

Biocatalysis offers a sustainable approach to drug synthesis, leveraging the high selectivity
and efficiency of enzymes. This review explores the application of biocatalysis in the early …

The use of antibiotics is threatened by the emergence and spread of multidrug-resistant
strains of bacteria. Thus, there is a need to develop antibiotics that address new targets. In …

With increasing rates of resistance toward commonly used antibiotics, especially among
Gram-negative bacteria, there is renewed interested in polymyxins. Polymyxins are …

Thanatin is a β-hairpin antimicrobial peptide cyclised by a single disulfide bond that has
shown potent broad-spectrum activity towards bacterial and fungal pathogens. Towards …

Peptide antibiotics have gathered attention given the urgent need to discover antimicrobials
with new mechanisms of action. Their extended role as immunomodulators makes them …

Solid-phase total synthesis of sandramycin (1), which is a C 2-symmetric cyclic
decadepsipeptide natural product, and its analogues is described. On-resin ester formation …

Seven novel macrocyclic drug candidates having quinoxaline, naphthalene and xylene
subunits were synthesized in order to investigate their antimicrobial suitability in combating …

The golden age of antibiotic discovery was marked not only by the discovery of numerous
new antibiotic structures but also by the recurring correlation of these antibiotics to two …

Este relatório descreve o percurso de aquisição de competências ao longo do 15º Curso de
Mestrado em Enfermagem, com especialização em Enfermagem Médico Cirúrgica, na Área …