Mitosis and cytokinesis are undoubtedly the most spectacular parts of the cell cycle. Errors in
the choreography of these processes can lead to aneuploidy or genetic instability, fostering …

Highlights•NEK7 is a vital component involved in the NLRP3 inflammasome
activation.•NEK7-licensed NLRP3 inflammasome activation includes multiple …

NIMA related Kinases (NEK7) plays an important role in spindle assembly and mitotic
division of the cell. Over expression of NEK7 leads to the progression of different cancers …

The NLRP3 inflammasome responds to microbes and danger signals by processing and
activating proinflammatory cytokines, including interleukin 1β (IL-1β) and IL-18. We found …

The NIMA-related kinases represent a family of serine/threonine kinases implicated in cell
cycle control. The founding member of this family, the NIMA kinase of Aspergillus nidulans …

Regulation of the centrosome, the major microtubule organizing centre in an animal cell, is
in large part controlled by cell cycle-dependent protein phosphorylation. Along with cyclin …

The Nek family of protein kinases in humans is composed of 11 members that share an
amino-terminal catalytic domain related to NIMA, an Aspergillus kinase involved in the …

Diabetic cardiomyopathy (DCM), a serious diabetic complication, is a kind of low-grade
inflammatory cardiovascular disorder. Due to the high risk of morbidity and mortality, DCM …

Genetic studies in yeast and Drosophila led to identification of cyclin-dependent kinases
(CDKs), Polo-like kinases (PLKs) and Aurora kinases as essential regulators of mitosis …

Nek6 and Nercc1 (also known as Nek9) belong to the NIMA family of protein kinases.
Nercc1 is activated in mitosis, whereupon it binds, phosphorylates and activates Nek6 …