Introduction Both vaccines and antiviral drugs represent the mainstay for preventing and
treating influenza. However, approved M2 ion channel inhibitors, neuraminidase inhibitors …

Influenza is an acute respiratory infectious disease caused by the influenza virus, affecting
people globally and causing significant social and economic losses. Due to the inevitable …

In response to the epidemic and pandemic threats caused by emerging respiratory viral
infections, a safe and efficient broad‐spectrum antiviral therapy at early onset of infection …

Introduction: The emergence of drug-resistant influenza virus strains highlights the need for
new antiviral therapeutics to combat future pandemic outbreaks as well as continuing …

Influenza (flu) virus is a serious threat to global health with the potential to generate
devastating pandemics. The availability of broad spectrum antiviral drugs is an unequaled …

Engaging the antibody-dependent cell-mediated cytotoxicity (ADCC) for killing of virus-
infected cells and secretion of antiviral cytokines and chemokines was incorporated as one …

The limited therapeutic options and increasing drug-resistance call for next-generation
influenza antivirals. Due to the essential function in viral replication and high sequence …

Influenza viruses are severe human pathogens that pose persistent threat to public health.
Each year more people die of influenza virus infection than that of breast cancer. Due to the …

Influenza is an acute respiratory infectious disease caused by influenza virus, leading to
huge morbidity and mortality in humans worldwide. Despite the availability of antivirals in the …

The propensity of influenza virus to develop resistance to commonly prescribed drugs
highlights the need for continuing development of new therapeutics. Biological and …