The blood vessel wall has a number of self‐healing properties, enabling it to minimize blood
loss and prevent or overcome infections in the event of vascular trauma. Endothelial cells …

Within blood vessels, endothelial cell–cell and cell–matrix adhesions are crucial to preserve
barrier function, and these adhesions are tightly controlled during vascular development …

The P-Rex family are Dbl-type guanine-nucleotide exchange factors for Rac family small G
proteins. They are distinguished from other Rac-GEFs through their synergistic mode of …

Objective: Small GTPase Rap1 (Ras-association proximate 1) is a novel, positive regulator
of NO release and endothelial function with a potentially key role in mechanosensing of …

Abstract Endothelial exocytosis of Weibel–Palade body (WPB) is one of the first lines of
defence against vascular injury. However, the mechanisms that control WPB exocytosis in …

Vascular endothelial cells contain unique rod-shaped secretory organelles, called Weibel-
Palade bodies (WPBs), which contain the hemostatic protein von Willebrand factor (VWF) …

Endothelial cells, forming a monolayer along blood vessels, intricately regulate vascular
hemostasis, inflammatory responses, and angiogenesis. A key determinant of these …

One of the most used and versatile methods to study number, dimensions, content and
localization of secretory organelles is confocal microscopy analysis. However, considerable …

Background Synthesis of the hemostatic protein von Willebrand factor (VWF) drives
formation of endothelial storage organelles called Weibel‐Palade bodies (WPBs). In the …

FMF is an autoinflammatory disease characterized by recurrent attacks and increased IL-1
synthesis owing to activation of the pyrin inflammasome. Although knowledge of the …