Epibatidine: a promising natural alkaloid in health

B Salehi, S Sestito, S Rapposelli, G Peron, D Calina… - Biomolecules, 2018 - mdpi.com
Epibatidine is a natural alkaloid that acts at nicotinic acetylcholine receptors (nAChRs). The
present review aims to carefully discuss the affinity of epibatidine and its synthetic …

Second-generation palladium catalyst system for transannular C–H functionalization of azabicycloalkanes

PJ Cabrera, M Lee, MS Sanford - Journal of the American …, 2018 - ACS Publications
This article describes the development of a second-generation catalyst system for the
transannular C–H functionalization of alicyclic amines. Pyridine-and quinoline-carboxylate …

Bicyclic β-amino acids

OO Grygorenko - Tetrahedron, 2015 - Elsevier
The field of β-amino acids and β-peptides has given rise to considerable interest in recent
decades. 1, 1 (a), 1 (b), 1 (c), 1 (d), 1 (e), 1 (f) β-Amino acids are widespread in the nature as …

[图书][B] Affinity chromatography

S Magdeldin - 2012 - books.google.com
Most will agree that one major achievement in the bio-separation techniques is affinity
chromatography. This coined terminology covers a myriad of separation approaches that …

Ligand-controlled stereodivergent 1, 3-dipolar cycloaddition of azomethine ylides with 3-methyl-4-nitro-5-styrylisoxazoles

K Liu, Y Xiong, ZF Wang, HY Tao… - Chemical …, 2016 - pubs.rsc.org
An unprecedented Ag (I)-catalyzed ligand-controlled stereodivergent 1, 3-dipolar
cycloaddition of azomethine ylides with 3-methyl-4-nitro-5-styrylisoxazoles has been …

Diastereoselective [3 + 2] Cycloaddition between Tertiary Amine N-Oxides and Substituted Alkenes to Access 7-Azanorbornanes

AH Cocolas, AM Lane, BS Musiak, EJ Chartier… - Organic …, 2024 - ACS Publications
We have developed a diastereoselective synthesis of 43 novel 7-azanorbornanes using
tertiary amine N-oxides and substituted alkenes. Our method uses an efficient [3+ 2] …

Synthetic enzyme-catalyzed multicomponent reaction for Isoxazol-5 (4 H)-one Syntheses, their properties and biological application; why should one study …

GHC Oliveira, LM Ramos, RKC de Paiva… - Organic & …, 2021 - pubs.rsc.org
In this work, we describe the application of a synthetic enzyme (synzyme) as the catalyst to
promote the multicomponent synthesis of isoxazol-5 (4H)-one derivatives. The catalytic …

Design, Synthesis, and Pharmacological Characterization of Novel Spirocyclic Quinuclidinyl‐Δ2‐Isoxazoline Derivatives as Potent and Selective Agonists of α7 …

C Dallanoce, P Magrone, C Matera, F Frigerio… - …, 2011 - Wiley Online Library
A set of racemic spirocyclic quinuclidinyl‐Δ2‐isoxazoline derivatives was synthesized using
a 1, 3‐dipolar cycloaddition‐based approach. Target compounds were assayed for binding …

Determination of acid dissociation constants of compounds active at neuronal nicotinic acetylcholine receptors by means of electrophoretic and potentiometric …

G Roda, C Dallanoce, G Grazioso, V Liberti… - Analytical …, 2010 - jstage.jst.go.jp
Neuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in the brain,
where they primarily modulate neurotransmitter release and, to a lesser extent, participate to …

Silver-catalyzed diastereo-and enantioselective Michael addition and 1, 3-dipolar cycloaddition reactions of imino esters to 3-methyl-4-nitro-5-styrylisoxazoles

S Kato, Y Suzuki, K Suzuki, R Haraguchi… - The Journal of …, 2018 - ACS Publications
The AgOAc/ThioClickFerrophos complex catalyzed conjugate additions and 1, 3-dipolar
cycloadditions of 3-methyl-4-nitro-5-styrylisoxazoles with 1-pyrroline-5-carboxylates and …