Hormetic mechanisms

EJ Calabrese - Critical reviews in toxicology, 2013 - Taylor & Francis
This article provides the first extensive documentation of mechanisms of hormetic
dose/concentration responses. The mechanisms selected were principally those mediated …

Insights into bombesin receptors and ligands: highlighting recent advances

I Ramos-Álvarez, P Moreno, SA Mantey, T Nakamura… - Peptides, 2015 - Elsevier
This following article is written for Prof. Abba Kastin's Festschrift, to add to the tribute to his
important role in the advancement of the role of peptides in physiological, as well as …

Regulation of acinar cell function in the pancreas

JA Williams - Current opinion in gastroenterology, 2010 - journals.lww.com
Regulation of acinar cell function in the pancreas : Current Opinion in Gastroenterology
Regulation of acinar cell function in the pancreas : Current Opinion in Gastroenterology Log in or …

Hormetic effect of berberine attenuates the anticancer activity of chemotherapeutic agents

J Bao, B Huang, L Zou, S Chen, C Zhang, Y Zhang… - PloS one, 2015 - journals.plos.org
Hormesis is a phenomenon of biphasic dose response characterized by exhibiting
stimulatory or beneficial effects at low doses and inhibitory or toxic effects at high doses …

CCK1 and CCK2 receptors are expressed on pancreatic stellate cells and induce collagen production

MJ Berna, O Seiz, JF Nast, D Benten, M Bläker… - Journal of Biological …, 2010 - ASBMB
The gastrointestinal hormone cholecystokinin (CCK) can induce acute pancreatitis in
rodents through its action on acinar cells. Treatment with CCK, in combination with other …

Insulin protects pancreatic acinar cells from palmitoleic acid-induced cellular injury

A Samad, A James, J Wong, P Mankad… - Journal of Biological …, 2014 - ASBMB
Acute pancreatitis is a serious and sometimes fatal inflammatory disease where the
pancreas digests itself. The non-oxidative ethanol metabolites palmitoleic acid (POA) and …

Insulin protects pancreatic acinar cells from cytosolic calcium overload and inhibition of plasma membrane calcium pump

P Mankad, A James, AK Siriwardena, AC Elliott… - Journal of Biological …, 2012 - ASBMB
Acute pancreatitis is a serious and sometimes fatal inflammatory disease of the pancreas
without any reliable treatment or imminent cure. In recent years, impaired metabolism and …

Therapeutic potential for novel drugs targeting the type 1 cholecystokinin receptor

EE Cawston, LJ Miller - British journal of pharmacology, 2010 - Wiley Online Library
Cholecystokinin (CCK) is a physiologically important gastrointestinal and neuronal peptide
hormone, with roles in stimulating gallbladder contraction, pancreatic secretion …

PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors

Y Ni, J Sinnett-Smith, SH Young, E Rozengurt - PloS one, 2013 - journals.plos.org
We examined whether protein kinase D1 (PKD1) mediates negative feeback of PI3K/Akt
signaling in intestinal epithelial cells stimulated with G protein-coupled receptor (GPCR) …

[HTML][HTML] The p21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis …

B Nuche-Berenguer, I Ramos-Álvarez… - Biochimica et Biophysica …, 2016 - Elsevier
In a recent study we explored Group-1-p21-activated kinases (GP. 1-PAKs) in rat pancreatic
acini. Only PAK2 was present; it was activated by gastrointestinal-hormones …