Snake Venom PLA2, a Promising Target for Broad‐Spectrum Antivenom Drug Development

H Xiao, H Pan, K Liao, M Yang… - BioMed research …, 2017 - Wiley Online Library
Snakebite envenomation is a neglected global health problem, causing substantial mortality,
disability, and psychological morbidity, especially in rural tropical and subtropical zones …

[HTML][HTML] Crotoxin: novel activities for a classic β-neurotoxin

SC Sampaio, S Hyslop, MRM Fontes… - Toxicon, 2010 - Elsevier
Crotoxin, the main toxin of South American rattlesnake (Crotalus durissus terrificus) venom,
was the first snake venom protein to be purified and crystallized. Crotoxin is a heterodimeric …

Snake Venomics of the Central American Rattlesnake Crotalus simus and the South American Crotalus durissus Complex Points to Neurotoxicity as an Adaptive Paedomorphic …

JJ Calvete, L Sanz, P Cid, P de la Torre… - Journal of proteome …, 2010 - ACS Publications
We report a comparative venomic and antivenomic characterization of the venoms of
newborn and adult specimens of the Central American rattlesnake, Crotalus simus, and of …

Snake venomics and antivenomics of Crotalus durissus subspecies from Brazil: assessment of geographic variation and its implication on snakebite management

J Boldrini-França, C Corrêa-Netto, MMS Silva… - Journal of …, 2010 - Elsevier
We report the comparative proteomic and antivenomic characterization of the venoms of
subspecies cascavella and collilineatus of the Brazilian tropical rattlesnake Crotalus …

Evaluation of pro-inflammatory events induced by Bothrops alternatus snake venom

S Echeverria, E Leiguez, C Guijas… - Chemico-Biological …, 2018 - Elsevier
Inflammation is a major local feature of envenomation by bothropic snakes being
characterized by a prominent local edema, pain, and extensive swelling. There are reports …

Physicochemical and biological characterization of nanovenoms, a new tool formed by silica nanoparticles and Crotalus durissus terrificus venom

FG Baudou, L Fusco, E Giorgi, E Diaz… - Colloids and Surfaces B …, 2020 - Elsevier
Nanoparticles (NPs) are being studied due to their potential use as therapeutic and
immunomodulatory tools, including their ability to transport antigens with the aim to induce a …

Exploring the potential effect of phospholipase A2 antibody to extend beef shelf-life in a beef liposome model system

CKY Chun, M Roth, R Welti, MP Richards, WW Hsu… - Meat Science, 2023 - Elsevier
The objective of this study was to elucidate the effect of phospholipase A2 (PLA2) and a
PLA2 antibody (aPLA2) on phospholipid (PL) hydrolysis in beef and to understand how the …

Discovery of human scFvs that cross-neutralize the toxic effects of B. jararacussu and C. d. terrificus venoms

LC Silva, MB Pucca, G Pessenda, LB Campos… - Acta tropica, 2018 - Elsevier
Accidents involving venomous snakes are a public health problem worldwide, causing a
large number of deaths per year. In Brazil, the majority of accidents are caused by the …

Biological and proteomic characterization of the venom from Peruvian Andes rattlesnake Crotalus durissus

CR Rodrigues, DAM Molina, DLN de Souza… - Toxicon, 2022 - Elsevier
Abstract The Peruvian rattlesnake Crotalus durissus is a venomous species that is restricted
to the Peruvian Departments of Puno and Madre de Dios. Although clinically meaningful in …

Potential low-impact immunogen for the production of anti-bothropic serum: Bothrops alternatus venom treated with Na2EDTA

GL Lopez, A Van de Velde, D Hernández, S Bustillo… - Toxicon, 2024 - Elsevier
This study proposes an alternative method using Na 2 EDTA to neutralize B. alternatus
venom and using it as an immunogen from the start of inoculation to minimize side effects …