The myoD gene converts many differentiated cell types into muscle. MyoD is a member of
the basic-helix-loop-helix family of proteins; this 68-amino acid domain in MyoD is …

The expression of Myod is sufficient to convert a fibroblast to a skeletal muscle cell, and, as
such, is a model system in developmental biology for studying how a single initiating event …

Recent findings show that even the brief inactivation of a single oncogene might be sufficient
to result in the sustained loss of a neoplastic phenotype. It is therefore possible that the …

DrosophiIa and Caenorhabditis elegans, however, the mechanisms that establish complex
cellular phenotypes in vertebrates have been more difficult to approach. The recent …

The experiments reported here document that the tumor suppressor retinoblastoma protein
(pRB) plays an important role in the production and maintenance of the terminally …

Adeno-associated viruses (AAV) are ubiquitous in the human population (> 90% of adults
are seropositive) but have never been implicated as the cause of any disease. They were …

In muscle cells, as in a variety of cell types, proliferation and differentiation are mutually
exclusive events controlled by a balance of opposing cellular signals. Members of the MyoD …

Introduction Skeletal muscle fibres are permanent multinucleated, non-mitotic cells.
Consequently, there is considerable interest in how such a unique cell type is formed …

The product of the proto-oncogene Jun inhibits myogenesis. Constitutive expression of Jun
in myoblasts interferes with the expression and the function of MyoD protein. In transient …

The objective of the current review is to critically examine the literature on the activity of the
phorbol esters in in vitro systems. It is hoped that the review may offer new perspectives for …